Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
464-03-011 ISMRM Abstract

Abnormal brain dynamic functional changes in amyotrophic lateral sclerosis

Primary: Brain Function and fMRI - fMRI Analysis
Secondary: Neuro - Other Neurodegeneration
464-03-011 · Neurodegenerative Diseases · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row E
Keywords: Rs-fMRI Dynamic ALFF DFC
Accepted
Xinyi Yu 1,2, Haining Li3, Qiuli Zhang1, Shan Wu1, Tao Lu1, Qianqian Duan1, Fangfang Hu4, Jiaoting Jin4, Yi Chen5, Ming Zhang1,2
1Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
2School of Future Technology, Xi'an Jiaotong University, Xi'an, China
3Department of PET/CT, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
4Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
5Department of MRI, Yulin Hospital The First Affiliated Hospital of Xi’an Jiaotong University, China
Presenting Author: Xinyi Yu

Synopsis

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References

1. Goutman SA, Hardiman O, Al-Chalabi A, et al. Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis. Lancet Neurol. 2022;21(5):480-493. doi:10.1016/S1474-4422(21)00465-8 [doi]
2. Kucyi A, Hove MJ, Esterman M, et al. Dynamic Brain Network Correlates of Spontaneous Fluctuations in Attention. Cereb Cortex N Y N 1991. 2017;27(3):1831-1840. doi:10.1093/cercor/bhw029 [doi]
3. Ince PG, Highley JR, Kirby J, et al. Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology. Acta Neuropathol (Berl). 2011;122(6):657-671. doi:10.1007/s00401-011-0913-0 [doi]
4. Foerster BR, Callaghan BC, Petrou M, et al. Decreased motor cortex γ-aminobutyric acid in amyotrophic lateral sclerosis. Neurology. 2012;78(20):1596-1600. doi:10.1212/WNL.0b013e3182563b57 [doi]
5. Foerster BR, Pomper MG, Callaghan BC, et al. An imbalance between excitatory and inhibitory neurotransmitters in amyotrophic lateral sclerosis revealed by use of 3-T proton magnetic resonance spectroscopy. JAMA Neurol. 2013;70(8):1009-1016. doi:10.1001/jamaneurol.2013.234 [doi]
6. Schoenfeld MA, Tempelmann C, Gaul C, et al. Functional motor compensation in amyotrophic lateral sclerosis. J Neurol. 2005;252(8):944-952. doi:10.1007/s00415-005-0787-y [doi]
7. Qiu T, Zhang Y, Tang X, et al. Precentral degeneration and cerebellar compensation in amyotrophic lateral sclerosis: A multimodal MRI analysis. Hum Brain Mapp. 2019;40(12):3464-3474. doi:10.1002/hbm.24609 [doi]

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http://echo.ismrm.org/p/ISMRM2026/464-03-011