369-03-007 ISMRM Abstract

Multimodal MRI Tracks Synergistic Neurovascular Repair with MSC-Exosomes and Low-Intensity Pulsed Ultrasound after Rat MCAO

Primary: Preclinical Animal & in vitro MR - Small Animals

Secondary: Neuro - Stroke and Cerebrovascular Disorders

369-03-007 · Multiparametric MRI in Stroke · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row J

Keywords: Diffusion-Weighted Imaging 3.0T magnetic resonance imaging Diffusion MRI perfusion. IVIM Cerebral infarction Cerebral blood flow (CBF)

Accepted

Tiefeng Li ^1,2, Sicong Wang³, Ao Zhang^1,2, Qi Wang^1,2, Wenbiao Yang^1,4, Lanxiang Liu¹

¹Department of Magnetic Resonance Imaging, Qinhuangdao Municipal No. 1 Hospital, Qinhuangdao, Hebei, Qinhuangdao 066000，Hebei Province, China

²Graduate School, Hebei Medical University, Shijiazhuang, China

³MRI Research, GE Healthcare, Beijing, China

⁴Chengde Medical University, Chengde, China

Presenting Author: Tiefeng Li

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References

1. Ng F, Churilov L, Yassi N, et al. Microvascular Dysfunction in Blood-Brain Barrier Disruption and Hypoperfusion Within the Infarct Posttreatment Are Associated With Cerebral Edema. STROKE. 2021;53(0039-2499):1597-1605.doi: 10.1161/STROKEAHA.121.036104 [doi]

2. Xiong Y, Song J, Huang X, et al. Exosomes Derived From Mesenchymal Stem Cells: Novel Effects in the Treatment of Ischemic Stroke. FRONT NEUROSCI-SWITZ. 2022/5/2 2022;16.doi: 10.3389/fnins.2022.899887 [doi]

3. Liu L, Du J, Zheng T, et al. Protective effect of low-intensity transcranial ultrasound stimulation after differing delay following an acute ischemic stroke. BRAIN RES BULL. 2019;146(0361-9230):22-27.doi: 10.1016/j.brainresbull.2018.12.004 [doi]

4. Chen R, Du W, Zhang X, et al. Protective effects of low-intensity pulsed ultrasound (LIPUS) against cerebral ischemic stroke in mice by promoting brain vascular remodeling via the inhibition of ROCK1/p-MLC2 signaling pathway. CEREB CORTEX. 2023;33(1047-3211):10984-10996.doi: 10.1093/cercor/bhad330 [doi]

5. Li B, Xi W, Bai Y, et al. FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke. NAT COMMUN. 2023/1/30 2023;14(1).doi: 10.1038/s41467-023-36008-y [doi]

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http://echo.ismrm.org/p/ISMRM2026/369-03-007