Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
301-04-005 ISMRM Abstract

Time and orientation-dependent transverse relaxation from magnetic susceptibility of realistic white matter microstructure

Primary: Contrast Mechanisms - Relaxometry
Secondary: Contrast Mechanisms - Susceptibility/QSM
301-04-005 · Innovations in Contrast Mechanisms for MRI · Monday, 11 May, 4:10 PM–6:00 PM · Hall 1A
Keywords: Diffusion Modeling Microstructure Susceptibility MRI simulation T2 relaxometry
Accepted
Anders D Sandgaard 1, Rafael Neto Henriques2,3, Noam Shemesh3, Sune N Jespersen1,4
1Center of functionally integrative neuroscience, Department of clinical medicine, Aarhus University, Aarhus, Denmark
2Institute of Biophysics and Biomedical Engineering, Faculty of Science, University of Lisbon, Lisbon, Portugal
3Champalimaud Research, Champalimaud Foundation, Lisboa, Portugal
4Department of physics and astronomy, Aarhus University, Aarhus, Denmark
Presenting Author: Anders D Sandgaard

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Kiselev VG, Novikov DS. Transverse NMR Relaxation in Biological Tissues. Vol 182.; 2018:149-168. doi:10.1016/j.neuroimage.2018.06.002 [doi]
2. Winther S, Lundell H, Rafael-Patiño J, Andersson M, Thiran JP, Dyrby TB. Susceptibility-induced internal gradients reveal axon morphology and cause anisotropic effects in the diffusion-weighted MRI signal. Sci Reports 2024 141. 2024;14(1):1-18. doi:10.1038/s41598-024-79043-5 [doi]
3. Denk C, Torres EH, Mackay A, Rauscher A. The influence of white matter fibre orientation on MR signal phase and decay. NMR Biomed. 2011;24(3):246-252. doi:10.1002/NBM.1581 [doi]
4. Lee J, van Gelderen P, Kuo LW, Merkle H, Silva AC, Duyn JH. T2*-based fiber orientation mapping. Neuroimage. 2011;57(1):225-234. doi:10.1016/J.NEUROIMAGE.2011.04.026 [doi]
5. Bender B, Klose U. The in vivo influence of white matter fiber orientation towards B0 on T2* in the human brain. NMR Biomed. 2010;23(9):1071-1076. doi:10.1002/NBM.1534 [doi]
6. Tax CMW, Kleban E, Chamberland M, Baraković M, Rudrapatna U, Jones DK. Measuring compartmental T2-orientational dependence in human brain white matter using a tiltable RF coil and diffusion-T2 correlation MRI. Neuroimage. 2021;236. doi:10.1016/J.NEUROIMAGE.2021.117967 [doi]
7. Kor D, Birkl C, Ropele S, et al. The role of iron and myelin in orientation dependent R2* of white matter. NMR Biomed. 2019;32(7):e4092. doi:10.1002/NBM.4092 [doi]
8. Birkl C, Doucette J, Fan M, Hernández-Torres E, Rauscher A. Myelin water imaging depends on white matter fiber orientation in the human brain. Magn Reson Med. 2021;85(4):2221-2231. doi:10.1002/MRM.28543 [doi]
9. Lenz C, Berger C, Bauer M, Scheurer E, Birkl C. Sensitivity of fiber orientation dependent to temperature and post mortem interval. Magn Reson Med. 2021;86(5):2703-2715. doi:10.1002/MRM.28874 [doi]
10. Aggarwal M, Kageyama Y, Li X, Van Zijl PC. B0-orientation dependent magnetic susceptibility-induced white matter contrast in the human brainstem at 11.7T. Magn Reson Med. 2016;75(6):2455-2463. doi:10.1002/MRM.26208/ASSET/SUPINFO/MRM26208-SUP-0001-SUPPFIG1.DOCX [doi]
11. Ruh A, Emerich P, Scherer H, Novikov DS, Kiselev VG. Observation of magnetic structural universality and jamming transition with NMR. J Magn Reson. 2023;353:107476. doi:10.1016/j.jmr.2023.107476 [doi]
12. Abdollahzadeh A, Coronado-Leija R, Lee HH, Sierra A, Fieremans E, Novikov DS. Scattering approach to diffusion quantifies axonal damage in brain injury. Published online January 30, 2025. Accessed April 14, 2025. https://arxiv.org/abs/2501.18167v1
13. Andersson M, Kjer HM, Rafael-Patino J, et al. Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure–function relationship. Proc Natl Acad Sci U S A. 2021;117(52):33649-33659. doi:10.1073/PNAS.2012533117 [doi]
14. Ronen I, Budde M, Ercan E, Annese J, Techawiboonwong A, Webb A. Microstructural organization of axons in the human corpus callosum quantified by diffusion-weighted magnetic resonance spectroscopy of N-acetylaspartate and post-mortem histology. Brain Struct Funct. 2014;219(5):1773-1785. doi:10.1007/s00429-013-0600-0 [doi]
15. Novikov DS, Jensen JH, Helpern JA, Fieremans E. Revealing mesoscopic structural universality with diffusion. Proc Natl Acad Sci U S A. 2014;111(14):5088-5093. doi:10.1073/pnas.1316944111 [doi]
16. Sandgaard AD, Sune |, Jespersen N. Predicting Mesoscopic Larmor Frequency Shifts in White Matter With Diffusion MRI—A Monte Carlo Study in Axonal Phantoms. NMR Biomed. 2025;38(3):e70004. doi:10.1002/NBM.70004 [doi]
17. Sandgaard AD, Kiselev VG, Henriques RN, Shemesh N, Jespersen SN. Incorporating the effect of white matter microstructure in the estimation of magnetic susceptibility in ex vivo mouse brain. Magn Reson Med. Published online September 29, 2023. doi:10.1002/MRM.29867 [doi]
18. Jensen JH, Russell Glenn G, Helpern JA. Fiber ball imaging. Neuroimage. 2016;124(Pt A):824-833. doi:10.1016/j.neuroimage.2015.09.049 [doi]
19. Jones DK, Horsfield MA, Simmons A. Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magn Reson Med. 1999;42(3):515-525. doi:10.1002/(SICI)1522-2594(199909)42:3<515::AID-MRM14>3.0.CO;2-Q [doi]
20. Shin HG, Lee J, Yun YH, et al. χ-separation: Magnetic susceptibility source separation toward iron and myelin mapping in the brain. Neuroimage. 2021;240:118371. doi:10.1016/J.NEUROIMAGE.2021.118371 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/301-04-005