Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
461-05-013 ISMRM Abstract

Time-STAMP MRI as a Functional Probe of CSF Dynamics: Towards Task-Based Evaluation of Chiari and ETV Patients

Primary: Neuro - Neurofluids
Secondary: Neuro - Spinal Cord
461-05-013 · Advances in Neuroimaging and Biomarkers for Brain Health and Disease · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row B
Keywords: Chiari Malformation Aqueductal Stenosis Noncommunicating Obstructive Hydrocephalus
Accepted
Clio Gonzalez Zacarias 1,2, Isabella Friedli3, Lucas J Conner4, Isabel Torres5,6, Matthew T Borzage7,8,9, Anand Joshi10, Theodore Calleja5, Marquis Chapman11, Noel F Arugay11, Madison E Gutierrez1, Eamon K Doyle11,12, Jason S Hauptman4, Andrew E Roman13, Kevin S King14, Diane Aum1, Mark D Krieger1, John C Wood2,8, J. Gordon McComb1, Stefan Blüml11, Peter Chiarelli4,14,15
1Division of Neurosurgery, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, United States of America
2Division of Cardiology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, United States of America
3Department of Biological Sciences, University of Southern California, Los Angeles, United States of America
4Division of Neurosurgery, Phoenix Children's Hospital, Phoenix, United States of America
5Department of Radiology, Children's Hospital of Los Angeles, Los Angeles, United States of America
6Rudi Shulte Research Institute, Santa Barbara, United States of America
7Pediatrics, Division of Neonatology, Children's Hospital Los Angeles, Los Angeles, United States of America
8Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, United States of America
9USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, United States of America
10Electrical and Computer Engineering, University of Southern California, Los Angeles, United States of America
11Department of Radiology and Pediatrics, Children's Hospital Los Angeles, Los Angeles, United States of America
12Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, United States of America
13Barrow Neurological Institute, Phoenix, United States of America
14Barrow Neurological Insititute, Phoenix, United States of America
15Division of Neurosurgery, Children's Hospital of Los Angeles, Los Angeles, United States of America
Presenting Author: Clio Gonzalez Zacarias

Synopsis

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References

1. Kollmeier JM, Gürbüz-Reiss L, Sahoo P, et al. Deep breathing couples CSF and venous flow dynamics. Scientific Reports. 2022;12(1):2568.
2. Laganà MM, Di Tella S, Ferrari F, et al. Blood and cerebrospinal fluid flow oscillations measured with real-time phase-contrast MRI: breathing mode matters. Fluids and Barriers of the CNS. 2022;19(1):100.
3. Liu P, Owashi K, Monnier H, Metanbou S, Capel C, Balédent O. Validating the accuracy of real-time phase-contrast MRI and quantifying the effects of free breathing on cerebrospinal fluid dynamics. Fluids and Barriers of the CNS. 2024;21(1):25.
4. Heiss JD. Cerebrospinal Fluid Hydrodynamics in Chiari I Malformation and Syringomyelia: Modeling Pathophysiology. Neurosurgery Clinics of North America. 2023;34(1):81-90.
5. Gutierrez ME, Torres I, Ha J, et al. Time-STAMP MRI of CSF motion for evaluation of Chiari malformation and endoscopic third ventriculostomy. Journal of Neurosurgery: Pediatrics. 2025;36(2):208-216.
6. Borzage M, Ponrartana S, Tamrazi B, et al. A new MRI tag-based method to non-invasively visualize cerebrospinal fluid flow. Child's Nervous System. 2018;34(9):1677-1682.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/461-05-013