Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
366-02-005 ISMRM Abstract

Modulatory influence of pain catastrophizing on irritable bowel syndrome via brain-spinal cord integration mechanisms

Primary: Brain Function and fMRI - fMRI Analysis
Secondary: Analysis Methods - Data Processing
366-02-005 · Brain-Body Axis · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row G
Keywords: Spinal Cord Irritable bowel syndrome Brain gray matter volumes Pain catastrophizing Partial least-squares correlation analysis
Accepted
Chenxi Wang 1,2,3, Jixin Liu4, Wen Wang5
1Tangdu Hospital, Fourth Military Medical University — Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, xi'an, China
2Tangdu Hospital, Fourth Military Medical University — Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province,7T MRI Precision Neurology Platform of Shaanxi Province, xi'an, China
3Tangdu Hospital, Fourth Military Medical University, Xi'an, China
4School of Life Science and Technology, Xidian University, Guangzhou, China
5Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, China
Presenting Author: Chenxi Wang

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References

1. Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M., Rajilić-Stojanović, M., Schemann, M., Schwille-Kiuntke, J., Simren, M., Zipfel, S., & Spiller, R. C. (2016). Irritable bowel syndrome. Nature reviews. Disease primers, 2, 16014. https://doi.org/10.1038/nrdp.2016.14 [doi]
2. Banerjee, A., Sarkhel, S., Sarkar, R., & Dhali, G. K. (2017). Anxiety and Depression in Irritable Bowel Syndrome. Indian journal of psychological medicine, 39(6), 741–745. https://doi.org/10.4103/IJPSYM.IJPSYM_46_17 [doi]
3. Eijsbouts, C., Zheng, T., Kennedy, N. A., Bonfiglio, F., Anderson, C. A., Moutsianas, L., Holliday, J., Shi, J., Shringarpure, S., 23andMe Research Team, Voda, A. I., Bellygenes Initiative, Farrugia, G., Franke, A., Hübenthal, M., Abecasis, G., Zawistowski, M., Skogholt, A. H., Ness-Jensen, E., Hveem, K., … Parkes, M. (2021). Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders. Nature genetics, 53(11), 1543–1552. https://doi.org/10.1038/s41588-021-00950-8 [doi]
4. Staudacher, H. M., Black, C. J., Teasdale, S. B., Mikocka-Walus, A., & Keefer, L. (2023). Irritable bowel syndrome and mental health comorbidity - approach to multidisciplinary management. Nature reviews. Gastroenterology & hepatology, 20(9), 582–596. https://doi.org/10.1038/s41575-023-00794-z [doi]
5. Mayer, E. A., Ryu, H. J., & Bhatt, R. R. (2023). The neurobiology of irritable bowel syndrome. Molecular psychiatry, 28(4), 1451–1465. https://doi.org/10.1038/s41380-023-01972-w [doi]

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http://echo.ismrm.org/p/ISMRM2026/366-02-005