Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
631-02-009 / 631-02-009 ISMRM Abstract

Intrinsic Waveguide MR Elastography of the Human Brain

Primary: Contrast Mechanisms - Elastography
Secondary: Neuro - Neurofluids
631-02-009 · Everything About Contrast Mechanism · Thursday, 14 May, 1:40 PM–3:16 PM · Roof Terrace
631-02-009 · Everything About Contrast Mechanism · Thursday, 14 May, 1:40 PM–3:16 PM · Roof Terrace
Keywords: MR elastography Anisotropy Elasiticity tensor Intrinsic MR elastography (iMRE)
Accepted
Kulam Najmudeen Magdoom1,2,3,4,5, Julian A Rey1,5,6, Alexandru V Avram1,5, Joelle Sarlls5,7, Anthony J Romano8, Szymczak G William8, Peter J Basser1,5
1Section on Quantitative Imaging and Tissue Sciences (SQITS), Eunice Kennedy Shriver - National Institute of Child Health and Human Development (NICHD), Bethesda, United States of America
2The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, United States of America
3Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, United States of America
4Uniformed Services University of the Health Sciences, Bethesda, United States of America
5National Institutes of Health, Bethesda, United States of America
6National Institute of General Medical Sciences, Bethesda, United States of America
7National institute of of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), BETHESDA, United States of America
8Naval Research Laboratory, Washington DC, United States of America
Presenting Author: Mihika Gangolli

Synopsis

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References

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2. Basser, Peter J., James Mattiello, and Denis LeBihan. "MR diffusion tensor spectroscopy and imaging." Biophysical journal 66.1 (1994): 259-267.
3. Smith, D. R., Caban-Rivera, D. A., McGarry, M. D., Williams, L. T., McIlvain, G., Okamoto, R. J., ... & Johnson, C. L. (2022). Anisotropic mechanical properties in the healthy human brain estimated with multi-excitation transversely isotropic MR elastography. Brain multiphysics, 3, 100051.
4. Magdoom, K. N., Avram, A. V., Sarlls, J. E., & Basser, P. J. (2025). In vivo palpation of anisotropic human brain tissue using MRI. bioRxiv, 2025-06.
5. Romano, A., Scheel, M., Hirsch, S., Braun, J., & Sack, I. (2012). In vivo waveguide elastography of white matter tracts in the human brain. Magnetic resonance in medicine, 68(5), 1410-1422.
6. Weaver, John B., et al. "Brain mechanical property measurement using MRE with intrinsic activation." Physics in Medicine & Biology 57.22 (2012): 7275.
7. Burman Ingeberg, M., Van Houten, E., & Zwanenburg, J. J. M. (2023). Estimating the viscoelastic properties of the human brain at 7 T MRI using intrinsic MRE and nonlinear inversion. Human brain mapping, 44(18), 6575–6591. https://doi.org/10.1002/hbm.26524 [doi]
8. Andersson, Jesper LR, Stefan Skare, and John Ashburner. "How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging." Neuroimage 20.2 (2003): 870-888.
9. Sinkus, R., et al. "Imaging anisotropic and viscous properties of breast tissue by magnetic resonance‐elastography." Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine 53.2 (2005): 372-387.
10. Cowin, S. C. (1989). Properties of the anisotropic elasticity tensor. The Quarterly Journal of Mechanics and Applied Mathematics, 42(2), 249-266.
11. Poncelet, B. P., Wedeen, V. J., Weisskoff, R. M., & Cohen, M. S. (1992). Brain parenchyma motion: measurement with cine echo-planar MR imaging. Radiology, 185(3), 645-651.
12. Sloots, J. J., Biessels, G. J., & Zwanenburg, J. J. (2020). Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI. Neuroimage, 210, 116581.
13. Hiscox, Lucy V., et al. "Magnetic resonance elastography (MRE) of the human brain: technique, findings and clinical applications." Physics in Medicine & Biology 61.24 (2016): R401.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/631-02-009