Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026
· Cape Town, South Africa
669-02-008
ISMRM Abstract
Quantitative MRI Biomarkers of Myelin: Cross-Validation and Diagnostic Performance in Multiple Sclerosis
Primary:
Neuro - Multiple Sclerosis
Secondary:
Neuro - White Matter
669-02-008 · Neuroimaging Biomarkers Across the Spectrum of Brain Disorders
· Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row J
Accepted
James Lo1,2, Sarah Tang1, Nathan Chan1, Dylan Tran1, Jiyo S Athertya1, Mohamad Amin Cheraghi1, Soo Hyun Shin 1, Jiang Du1,2,3, Graeme M Bydder1, Yajun Ma1
1University of California, Berkeley, United States of America
2Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, United States of America
3Radiology Service, VA San Diego Healthcare System, La Jolla, California, San Diego, United States of America
Presenting Author: Soo Hyun Shin
Synopsis
Motivation:
Goals:
Approach:
Results:
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1. Stadelmann C, Timmler S, Barrantes-Freer A, Simons M. Myelin in the Central Nervous System: Structure, Function, and Pathology. Physiological Reviews. 2019;99(3):1381-1431. doi:10.1152/physrev.00031.2018 [doi]
2. Ma YJ, Jang H, Wei Z, et al. Myelin Imaging in Human Brain Using a Short Repetition Time Adiabatic Inversion Recovery Prepared Ultrashort Echo Time (STAIR-UTE) MRI Sequence in Multiple Sclerosis. Radiology. 2020;297(2):392-404. doi:10.1148/radiol.2020200425 [doi]
3. Ma Y, Jang H, Lombardi AF, Corey‐Bloom J, Bydder GM. Myelin water imaging using a short‐TR adiabatic inversion‐recovery (STAIR) sequence. Magn Reson Med. 2022;88(3):1156-1169. doi:10.1002/mrm.29287 [doi]
4. Piredda GF, Hilbert T, Thiran J, Kober T. Probing myelin content of the human brain with MRI: A review. Magn Reson Med. 2021;85(2):627-652. doi:10.1002/mrm.28509 [doi]
5. Van Der Weijden CWJ, Biondetti E, Gutmann IW, et al. Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status. Brain. 2023;146(4):1243-1266. doi:10.1093/brain/awac436 [doi]
6. Tozer D, Ramani A, Barker GJ, Davies GR, Miller DH, Tofts PS. Quantitative magnetization transfer mapping of bound protons in multiple sclerosis. Magn Reson Med. 2003;50(1):83-91. doi:10.1002/mrm.10514 [doi]
7. Filippi M, Rocca MA, Minicucci L, et al. Magnetization transfer imaging of patients with definite MS and negative conventional MRI. Neurology. 1999;52(4):845-845. doi:10.1212/wnl.52.4.845 [doi]
8. Ma Y, Chang EY, Carl M, Du J. Quantitative magnetization transfer ultrashort echo time imaging using a time‐efficient 3D multispoke Cones sequence. Magn Reson Med. 2018;79(2):692-700. doi:10.1002/mrm.26716 [doi]
9. Samson RS, Cardoso MJ, Muhlert N, et al. Investigation of outer cortical magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups. Mult Scler. 2014;20(10):1322-1330. doi:10.1177/1352458514522537 [doi]
10. Ma Y, Zhao W, Wan L, et al. Whole knee joint T 1 values measured in vivo at 3T by combined 3D ultrashort echo time cones actual flip angle and variable flip angle methods. Magn Reson Med. 2019;81(3):1634-1644. doi:10.1002/mrm.27510 [doi]
11. Afshari R, Santini F, Heule R, Meyer CH, Pfeuffer J, Bieri O. One‐minute whole‐brain magnetization transfer ratio imaging with intrinsic B1 ‐correction. Magnetic Resonance in Med. 2021;85(5):2686-2695. doi:10.1002/mrm.28618 [doi]