Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
461-04-010 ISMRM Abstract

Exploring the Effects of Bariatric Surgery on Hepatic Metabolism: A Pilot 31P MRS Study

Primary: Contrast Mechanisms - Non-Proton
Secondary: Body - Liver
461-04-010 · Quantitative MRI Across the Body · Tuesday, 12 May, 2:35 PM–3:30 PM · Digital Posters Row B
Keywords: Diabetes Liver Bariatric surgery 31P-MRS 31P magnetic resonance spectroscopy
Accepted
Abi Spicer1,2, R Wilmington3,4, Chris R Bradley1,5, Susan Francis1,5, Guruprasad P Aithal2,6, Penny Gowland1,5, Iskandar Idris4,7, Stephen Bawden 1,2,5,8,9
1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom
2Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom
3Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom
4Bariatric Metabolic Institute, University Hospitals of Derby and Burton, United Kingdom
5NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom
6NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom
7University of Nottingham, Nottingham, United Kingdom
8Department of Medical Physics and Clinical Engineering, Swansea Bay University Health Board, Swansea, United Kingdom
9Institute of Life Sciences, Medical School, Swansea University, Swansea, United Kingdom
Presenting Author: Stephen Bawden

Synopsis

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References

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2. Lewis MC, Phillips ML, Slavotinek JP, Kow L, Thompson CH, Toouli J. Change in liver size and fat content after treatment with Optifast® very low calorie diet. Obes Surg [Internet]. 2006 Jun 1 [cited 2021 Jan 19];16(6):697–701. Available from: https://link.springer.com/article/10.1381/096089206777346682
3. Larson-Meyer DE, Heilbronn LK, Redman LM, Newcomer BR, Frisard MI, Anton S, et al. Effect of Calorie Restriction With or Without Exercise on Insulin Sensitivity, β-Cell Function, Fat Cell Size, and Ectopic Lipid in Overweight Subjects. Diabetes Care [Internet]. 2006 Jun 1 [cited 2024 Feb 12];29(6):1337–44. Available from: https://dx.doi.org/10.2337/dc05-2565 [doi]
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5. Al-Mrabeh A, Hollingsworth KG, Steven S, Taylor R. Morphology of the pancreas in type 2 diabetes: effect of weight loss with or without normalisation of insulin secretory capacity. Diabetologia [Internet]. 2016 Aug 1 [cited 2024 Feb 12];59(8):1753–9. Available from: https://link.springer.com/article/10.1007/s00125-016-3984-6
6. Kupriyanova Y, Zaharia OP, Bobrov P, Karusheva Y, Burkart V, Szendroedi J, et al. Early changes in hepatic energy metabolism and lipid content in recent-onset type 1 and 2 diabetes mellitus. J Hepatol. 2021 May 1;74(5):1028–37.
7. Szendroedi J, Chmelik M, Schmid AI, Nowotny P, Brehm A, Krssak M, et al. Abnormal hepatic energy homeostasis in type 2 diabetes. Hepatology [Internet]. 2009 Oct 1 [cited 2024 Mar 6];50(4):1079–86. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/hep.23093
8. Schmid AI, Szendroedi J, Chmelik M, Krššák M, Moser E, Roden M. Liver ATP Synthesis Is Lower and Relates to Insulin Sensitivity in Patients With Type 2 Diabetes. Diabetes Care [Internet]. 2011 Feb 1 [cited 2024 Jun 12];34(2):448–53. Available from: https://dx.doi.org/10.2337/dc10-1076 [doi]
9. Spicer A, Wilmington R, Lloyd-Brown S, Bradley C, Craig M, Simpson E, et al. Multiparametric MRI to study changes across the Surgical Journey in Bariatric Patients with Type 2 diabetes or Prediabetes. In: International Society of Magnetic Resonance in Medicine Annual Meeting. Singapore: ISMRM; 2024.
10. Schmid AI, Chmelík M, Szendroedi J, Krššák M, Brehm A, Moser E, et al. Quantitative ATP synthesis in human liver measured by localized 31P spectroscopy using the magnetization transfer experiment. NMR Biomed [Internet]. 2008 Jun [cited 2022 Nov 7];21(5):437–43. Available from: https://pubmed.ncbi.nlm.nih.gov/17910026/ [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/461-04-010