Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
367-05-007 ISMRM Abstract

Investigating magnetic susceptibility changes caused by hypoxia and myelin in the mouse brain at 9.4T using QSM and R2*

Primary: Contrast Mechanisms - Susceptibility/QSM
Secondary: Neuro - Multiple Sclerosis
367-05-007 · Neuroinflammation: Myelin and Iron · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row H
Keywords: Brain Quantitative Susceptibility Mapping (QSM) Demyelination R2 star Hypoxia
Accepted
Jeff F Dunn 1,2,3, Ty Makarowski1,2,3, Abbey Palset1,2,3, Ying Wu1,2,3, Hongfu Sun4, Yohan Yee1,2,3, Gabriel A Devenyi5,6
1Department of Radiology, University of Calgary, Calgary, Canada
2Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
3Cumming School of Medicine, University of Calgary, Calgary, Canada
4University of Newcastle, Newcastle, Australia
5Douglas Mental Health University Institute, Montreal, Canada
6McGill University, Montreal, Canada
Presenting Author: Jeff F Dunn

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References

1. Adingupu DD, Evans T, Soroush A, Hansen A, Jarvis S, Brown L, Dunn JF. Temporal Pattern of Cortical Hypoxia in Multiple Sclerosis and Its Significance on Neuropsychological and Clinical Measures of Disability. Ann Neurol. 2023;94(6):1067-79.doi:10.1002/ana.26769 [doi]
2. Adingupu DD, Soroush A, Hansen A, Twomey R, Dunn JF. Brain hypoxia, neurocognitive impairment, and quality of life in people post-COVID-19. J Neurol. 2023;270(7):3303-14.doi:10.1007/s00415-023-11767-2 [doi]
3. Johnson TW, Wu Y, Nathoo N, Rogers JA, Wee Yong V, Dunn JF. Gray Matter Hypoxia in the Brain of the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis. PLoS One. 2016;11(12):e0167196.doi:10.1371/journal.pone.0167196 [doi]
4. Chawla S, Kister I, Sinnecker T, Wuerfel J, Brisset JC, Paul F, Ge Y. Longitudinal study of multiple sclerosis lesions using ultra-high field (7T) multiparametric MR imaging. PLoS One. 2018;13(9):e0202918.doi:10.1371/journal.pone.0202918 [doi]
5. Hagemeier J, Ramanathan M, Schweser F, Dwyer MG, Lin F, Bergsland N, Weinstock-Guttman B, Zivadinov R. Iron-related gene variants and brain iron in multiple sclerosis and healthy individuals. Neuroimage Clin. 2018;17:530-40.doi:10.1016/j.nicl.2017.11.003 [doi]
6. Nathoo N, Agrawal S, Wu Y, Haylock-Jacobs S, Yong VW, Foniok T, Barnes S, Obenaus A, Dunn JF. Susceptibility-weighted imaging in the experimental autoimmune encephalomyelitis model of multiple sclerosis indicates elevated deoxyhemoglobin, iron deposition and demyelination. Mult Scler. 2013;19(6):721-31.doi:10.1177/1352458512460602 [doi]
7. Wiggermann V, Hametner S, Hernandez-Torres E, Kames C, Endmayr V, Kasprian G, Hoftberger R, Li DKB, Traboulsee A, Rauscher A. Susceptibility-sensitive MRI of multiple sclerosis lesions and the impact of normal-appearing white matter changes. NMR Biomed. 2017;30(8).doi:10.1002/nbm.3727 [doi]

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http://echo.ismrm.org/p/ISMRM2026/367-05-007