Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
406-02-005 ISMRM Abstract

Brain-wide mapping of perivascular networks with 14 Tesla MRI

Primary: Preclinical Animal & in vitro MR - Biomarkers
Secondary: Neuro - Neurofluids
406-02-005 · The Dynamic Brain: Flow, Pressure, and Exchange · Tuesday, 12 May, 1:40 PM–3:30 PM · Auditorium 2
Keywords: Neurofluids Perivascular spaces Glymphatic system MRI Ultra high field MRI
Accepted
Xiaoqing A Zhou 1, Xiaochen Liu1, Sangcheon Choi1, Weitao Man1, David Hike1, Nivetha Pasupathy1, Yuanyuan Jiang1, Xin Yu1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
Presenting Author: Xiaoqing A Zhou

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Benveniste, H. et al. The Glymphatic System and Waste Clearance with Brain Aging: A Review. Gerontology 65, 106-119 (2019). https://doi.org:10.1159/000490349
2. Da Mesquita, S. et al. Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease. Nature 560, 185-191 (2018). https://doi.org:10.1038/s41586-018-0368-8
3. Kress, B. T. et al. Impairment of paravascular clearance pathways in the aging brain. Annals of neurology 76, 845-861 (2014). https://doi.org:10.1002/ana.24271
4. Zeppenfeld, D. M. et al. Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains. JAMA Neurol 74, 91-99 (2017). https://doi.org:10.1001/jamaneurol.2016.4370
5. Marina, N. et al. Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow. Nature communications 11, 131 (2020). https://doi.org:10.1038/s41467-019-13956-y
6. Kisler, K., Nelson, A. R., Montagne, A. & Zlokovic, B. V. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nature Reviews Neuroscience 18, 419-434 (2017). https://doi.org:10.1038/nrn.2017.48
7. MacVicar, B. A. & Newman, E. A. Astrocyte regulation of blood flow in the brain. Cold Spring Harb Perspect Biol 7 (2015). https://doi.org:10.1101/cshperspect.a020388
8. Iliff, J. J. et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med 4, 147ra111 (2012). https://doi.org:10.1126/scitranslmed.3003748
9. Attwell, D. et al. Glial and neuronal control of brain blood flow. Nature 468, 232-243 (2010). https://doi.org:10.1038/nature09613
10. Iliff, J. J. et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med 4, 147ra111 (2012). https://doi.org:10.1126/scitranslmed.3003748
11. Holstein-Rønsbo, S. et al. Glymphatic influx and clearance are accelerated by neurovascular coupling. Nature neuroscience 26, 1042-1053 (2023). https://doi.org:10.1038/s41593-023-01327-2
12. Yu, X. et al. Sensory and optogenetically driven single-vessel fMRI. Nature methods 13, 337-340 (2016). https://doi.org:10.1038/nmeth.3765
13. He, Y. et al. Ultra-Slow Single-Vessel BOLD and CBV-Based fMRI Spatiotemporal Dynamics and Their Correlation with Neuronal Intracellular Calcium Signals. Neuron 97, 925-939 e925 (2018). https://doi.org:10.1016/j.neuron.2018.01.025

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/406-02-005