666-03-002 ISMRM Abstract

Multimodal imaging reveals sex-specific metabolic rewiring in the hAPP-J20 model of Alzheimer's disease

Primary: Neuro - Alzheimer's Disease

Secondary: Preclinical Animal & in vitro MR - Other Preclinical

666-03-002 · Neuro-Biomarkers · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row G

Keywords: Alzheimer's Disease FDG-PET Brain energy metabolism Metabolomics

Accepted

Tamara Vasilkovska ^1,2,3, Lydia M Le Page^1,2, Marina Radoul^1,2, Caroline Guglielmetti^1,2, Huihui Li³, Xiao Ji¹, Jeremy W Gordon¹, Ken Nakamura^3,4, Myriam Chaumeil^1,2

¹Department of Radiology and Biomedical Imaging, University Of California, San Francisco (UCSF), United States of America

²Physical Therapy & Rehabilitation Science, University Of California, San Francisco (UCSF), United States of America

³Gladstone Institutes, San Francisco, United States of America

⁴Department of Neurology, University Of California, San Francisco (UCSF), United States of America

Presenting Author: Tamara Vasilkovska

Synopsis

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References

1. Batra, R. et al. The landscape of metabolic brain alterations in Alzheimer’s disease. Alzheimers Dement 19, 980–998 (2023).

2. Ferreira, I. L., Resende, R., Ferreiro, E., Rego, A. C. & Pereira, C. F. Multiple defects in energy metabolism in Alzheimer’s disease. Curr. Drug Targets 11, 1193–1206 (2010).

3. Ryu, W.-I. et al. Brain cells derived from Alzheimer’s disease patients have multiple specific innate abnormalities in energy metabolism. Mol. Psychiatry 26, 5702–5714 (2021).

4. Mucke, L. et al. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J. Neurosci. 20, 4050–4058 (2000).

5. Wright, A. L. et al. Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer’s disease. PLoS ONE 8, e59586 (2013).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/666-03-002