Synopsis
Motivation:
Goals:
Approach:
Results:
663-04-010
ISMRM Abstract
IVIM and Cerebrovascular Reactivity MRI reveal early microvascular dysfunction surrounding White Matter Hyperintensities
Accepted
Full abstract & presentation
The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.
Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.
To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.
Log inReferences
1. Enzinger C, Smith S, Fazekas F, et al. Lesion probability maps of white matter hyperintensities in elderly individuals: Results of the Austrian stroke prevention study. J Neurol 2006; 253: 1064–1070.
2. 2001–2011: A Decade of the LADIS (Leukoaraiosis And DISability) Study: What Have We Learned about White Matter Changes and Small-Vessel Disease? Cerebrovasc Dis 2011; 32: 577–588.
3. Alber J, Alladi S, Bae H-J, et al. White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities. Alzheimer’s & Dementia: Translational Research & Clinical Interventions 2019; 5: 107–117.
4. Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. The Lancet Neurology 2013; 12: 822–838.
5. Wardlaw JM, Makin SJ, Valdés Hernández MC, et al. Blood‐brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study. Alzheimer’s & Dementia 2017; 13: 634–643.
6. Wardlaw JM, Smith C, Dichgans M. Small vessel disease: mechanisms and clinical implications. The Lancet Neurology 2019; 18: 684–696.
7. Maillard P, Fletcher E, Lockhart SN, et al. White Matter Hyperintensities and Their Penumbra Lie Along a Continuum of Injury in the Aging Brain. Stroke 2014; 45: 1721–1726.
8. Promjunyakul N, Lahna D, Kaye JA, et al. Characterizing the white matter hyperintensity penumbra with cerebral blood flow measures. NeuroImage: Clinical 2015; 8: 224–229.
9. Le Bihan D. What can we see with IVIM MRI? NeuroImage 2019; 187: 56–67.
10. Bergamino M, Nespodzany A, Baxter LC, et al. Preliminary Assessment of Intravoxel Incoherent Motion DIFFUSION‐WEIGHTED MRI ( IVIM‐DWI ) Metrics in Alzheimer’s Disease. J Magn Reson Imaging 2020; 52: 1811–1826.
11. Duering M, Finsterwalder S, Baykara E, et al. Free water determines diffusion alterations and clinical status in cerebral small vessel disease. Alzheimer’s & Dementia 2018; 14: 764–774.
12. Blair GW, Doubal FN, Thrippleton MJ, et al. Magnetic resonance imaging for assessment of cerebrovascular reactivity in cerebral small vessel disease: A systematic review. J Cereb Blood Flow Metab 2016; 36: 833–841.
13. Liu P, De Vis JB, Lu H. Cerebrovascular reactivity (CVR) MRI with CO2 challenge: A technical review. NeuroImage 2019; 187: 104–115.
14. Wiltgen T, McGinnis J, Schlaeger S, et al. LST-AI: A deep learning ensemble for accurate MS lesion segmentation. NeuroImage: Clinical 2024; 42: 103611.
15. Smith SM, Jenkinson M, Johansen-Berg H, et al. Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data. NeuroImage 2006; 31: 1487–1505.
16. Mazur-Rosmus W, Krzyżak AT. The effect of elimination of gibbs ringing, noise and systematic errors on the DTI metrics and tractography in a rat brain. Sci Rep 2024; 14: 15010.
17. Ohno N, Miyati T, Kobayashi S, et al. Modified triexponential analysis of intravoxel incoherent motion for brain perfusion and diffusion. Journal of Magnetic Resonance Imaging 2016; 43: 818–823.
18. Riexinger AJ, Martin J, Rauh S, et al. On the Field Strength Dependence of Bi- and Triexponential Intravoxel Incoherent Motion (IVIM) Parameters in the Liver. Journal of Magnetic Resonance Imaging 2019; 50: 1883–1892.
19. Hoffmann G, Schmitzer L, Kufer J, et al. Dynamic Susceptibility Contrast MRI and Arterial Spin Labeling reveals blood volume dependence of BOLD-based Cerebrovascular Reactivity. Proceedings of the International Society of Magnetic Resonance in Medicine, Honolulu, Hawaii, USA, 2025.
20. Brett M, Christoff K, Cusack R, et al. Using the talairach atlas with the MNI template. NeuroImage 2001; 13: 85.
21. Wardlaw JM, Smith C, Dichgans M. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. The Lancet Neurology 2013; 12: 483–497.
22. Lin H, Dai X, Su J, et al. Associations between microstructural tissue changes, white matter hyperintensity severity, and cognitive impairment: an intravoxel incoherent motion imaging study. Front Aging Neurosci 2023; 15: 1258105.
23. Van Dinther M, Voorter PH, Jansen JF, et al. Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging. J Cereb Blood Flow Metab 2022; 42: 718–737.
24. Levit A, Hachinski V, Whitehead SN. Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease. GeroScience 2020; 42: 445–465.
25. Maillard P, Lu H, Arfanakis K, et al. Instrumental validation of free water, peak‐width of skeletonized mean diffusivity, and white matter hyperintensities: MarkVCID neuroimaging kits. Alz & Dem Diag Ass & Dis Mo; 14. Epub ahead of print January 2022. DOI: 10.1002/dad2.12261. [doi]
26. Fernando MS, Simpson JE, Matthews F, et al. White Matter Lesions in an Unselected Cohort of the Elderly: Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury. Stroke 2006; 37: 1391–1398.
Cite this abstract
http://echo.ismrm.org/p/ISMRM2026/663-04-010