Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-02-005 ISMRM Abstract

Assessment of Voxelwise Longitudinal Changes in Tissue Microstructure Measured with MAP-MRI following mTBI

Primary: Neuro - Traumatic Brain Injury
Secondary: Diffusion - DWI/DTI/DKI
362-02-005 · Clinical Diffusion Neuro · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row C
Keywords: Traumatic brain injury Clinical application Diffusion-weighted MRI Longitudinal Studies MAP-MRI
Accepted
Mihika Gangolli 1,2, Neil Perkins3, Luca Marinelli4, Peter J Basser1, Alexandru V Avram1
1Section on Quantitative Tissue Imaging Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD, United States of America, United States of America
2The Military Traumatic Brain Injury Initiative (MTBI2), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, United States of America
3Division of Population Health Research (DiPHR), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD, United States of America, United States of America
4GE HealthCare Technology and Innovation Center, Niskayuna, United States of America
Presenting Author: Mihika Gangolli

Synopsis

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References

1. Bramlett, H. M. & Dietrich, W. D. Long-Term Consequences of Traumatic Brain Injury: Current Status of Potential Mechanisms of Injury and Neurological Outcomes. J Neurotrauma 32, 1834-1848 (2015). https://doi.org/10.1089/neu.2014.3352 [doi]
2. Adrian, H., Marten, K., Salla, N. & Lasse, V. Biomarkers of Traumatic Brain Injury: Temporal Changes in Body Fluids. eNeuro 3 (2016). https://doi.org/10.1523/ENEURO.0294-16.2016 [doi]
3. Maas, A. I. R. et al. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol 16, 987-1048 (2017). https://doi.org/10.1016/S1474-4422(17)30371-X [doi]
4. Palacios, E. M. et al. Diffusion Tensor Imaging Reveals Elevated Diffusivity of White Matter Microstructure that Is Independently Associated with Long-Term Outcome after Mild Traumatic Brain Injury: A TRACK-TBI Study. J Neurotrauma 39, 1318-1328 (2022). https://doi.org/10.1089/neu.2021.0408 [doi]
5. Ozarslan, E. et al. Mean apparent propagator (MAP) MRI: a novel diffusion imaging method for mapping tissue microstructure. Neuroimage 78, 16-32 (2013). https://doi.org/10.1016/j.neuroimage.2013.04.016 [doi]
6. Avram, A. V., Sarlls, J. E. & Basser, P. J. Measuring non-parametric distributions of intravoxel mean diffusivities using a clinical MRI scanner. Neuroimage 185, 255-262 (2019). https://doi.org/10.1016/j.neuroimage.2018.10.030 [doi]
7. Shetty, T. et al. Longitudinal Change in Diffusion Kurtosis Imaging Metrics as a Biomarker of Mild Traumatic Brain Injury. Neurology 92 (2019).
8. Pierpaoli, C. et al. in 18th Scientific Meeting of the International Society for Magnetic Resonance in Medicine. 1597.
9. Fischl, B. FreeSurfer. NeuroImage 62, 774-781 (2012). https://doi.org/10.1016/j.neuroimage.2012.01.021 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/362-02-005