Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
565-01-007 ISMRM Abstract

Elevated Choroid Plexus Blood Flow in NMOSD Linked to Cognitive and Emotional Deficits

Primary: Brain Function and fMRI - fMRI Analysis
Secondary: Neuro - Neuroinflammation
565-01-007 · Neuroinflammation: Fluids and Flow · Wednesday, 13 May, 8:20 AM–9:15 AM · Digital Posters Row F
Keywords: Choroid plexus Neuromyelitis optica spectrum disorder Arterial Spin Labelling (ASL) Cognitive Dysfunction Blood-Cerebrospinal Fluid Barrier
Accepted
Nan Meng 1, Xi Li1, Bing Liu1, Xiuzheng Yue2, Fuxin Ren1, Fei Gao1
1Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, China
2Clinical and Technical Support, Philips Healthcare (Beijing), Beijing, China
Presenting Author: Nan Meng

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References

1. Czarnecka D, Oset M, Karlińska I, Stasiołek M. Cognitive impairment in NMOSD-More questions than answers. Brain Behav. 2020 Nov;10(11):e01842. doi: 10.1002/brb3.1842. Epub 2020 Oct 6. PMID: 33022898; PMCID: PMC7667314. [doi] [pmid]
2. Saji E, Arakawa M, Yanagawa K, Toyoshima Y, Yokoseki A, Okamoto K, Otsuki M, Akazawa K, Kakita A, Takahashi H, Nishizawa M, Kawachi I. Cognitive impairment and cortical degeneration in neuromyelitis optica. Ann Neurol. 2013 Jan;73(1):65-76. doi: 10.1002/ana.23721. PMID: 23378324. [doi] [pmid]
3. Lazarevic I, Soldati S, Mapunda JA, Rudolph H, Rosito M, de Oliveira AC, Enzmann G, Nishihara H, Ishikawa H, Tenenbaum T, Schroten H, Engelhardt B. The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis. Fluids Barriers CNS. 2023 Jun 1;20(1):39. doi: 10.1186/s12987-023-00441-4. Erratum in: Fluids Barriers CNS. 2023 Jul 14;20(1):55. doi: 10.1186/s12987-023-00457-w. PMID: 37264368; PMCID: PMC10236715. [doi] [pmid]
4. Choi JD, Moon Y, Kim HJ, Yim Y, Lee S, Moon WJ. Choroid Plexus Volume and Permeability at Brain MRI within the Alzheimer Disease Clinical Spectrum. Radiology. 2022 Sep;304(3):635-645. doi: 10.1148/radiol.212400. Epub 2022 May 17. PMID: 35579521. [doi] [pmid]
5. Klistorner S, Barnett MH, Wang C, Parratt J, Yiannikas C, Klistorner A. Longitudinal enlargement of choroid plexus is associated with chronic lesion expansion and neurodegeneration in RRMS patients. Mult Scler. 2024 Apr;30(4-5):496-504. doi: 10.1177/13524585241228423. Epub 2024 Feb 6. PMID: 38318807; PMCID: PMC11010552. [doi] [pmid]
6. Kinoshita M, Okuno T. Autoimmune-mediated astrocytopathy. Inflamm Regen. 2023 Jul 18;43(1):39. doi: 10.1186/s41232-023-00291-5. PMID: 37461118; PMCID: PMC10353242. [doi] [pmid]
7. Chen X, Fu J, Luo Q, Han Y, Zheng Q, Xie M, Li Y. Altered volume and microstructural integrity of hippocampus in NMOSD. Mult Scler Relat Disord. 2019 Feb;28:132-137. doi: 10.1016/j.msard.2018.12.009. Epub 2018 Dec 12. PMID: 30594813. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/565-01-007