Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
405-02-002 ISMRM Abstract

Dynamic changes in sodium (23Na) neurite-fractions uncover the early phase of potentially reversible cellular energy distress

Primary: Neuro - Multiple Sclerosis
Secondary: Diffusion - Microstructure
405-02-002 · What's New in Multiple Sclerosis? · Tuesday, 12 May, 8:20 AM–10:10 AM · Ballroom West
Keywords: Multiple Sclerosis Neurite orientation dispersion and density imaging Sodium MRI Energy metabolism
Accepted
Juliette Dufour1,2, Mariem Hamzaoui2, Andrea Lazzarotto1,2, Théodore Soulier1,2, Renata Porciuncula Baptista3, Alexandre Vignaud3, Giacomo Boffa4, Matilde Inglese4, Sandro Romanzetti3,5, Iris Asllani6, Fawzi Boumezbeur3, Bruno Stankoff1,2, Benedetta Bodini1,2, Mara Cercignani 7
1Sorbonne Université, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière, Paris, France
2Paris Brain Institute, Paris, France
3CEA NeuroSpin, Paris-Saclay University, CNRS, Gif-Sur-Yvette, France
4Department of Neuroscience, University of Genoa, Genoa (GE), Italy
5Department of Neurology, RWTH Aachen University, Aachen, Germany
6Department of Clinical Neuroscience, Brighton and Sussex Medical School, University of Sussex, Falmer, BN1 9RR, England, United Kingdom
7School of Psychology, Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom
Presenting Author: Mara Cercignani

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References

1. Trapp BD, Stys PK. Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis. Lancet Neurol. mars 2009;8(3):280‑91. doi:10.1016/S1474-4422(09)70043-2 [doi]
2. Petracca M, Vancea RO, Fleysher L, Jonkman LE, Oesingmann N, Inglese M. Brain intra- and extracellular sodium concentration in multiple sclerosis: a 7 T MRI study. Brain. mars 2016;139(3):795‑806. doi:10.1093/brain/awv386 [doi]
3. Madelin G, Kline R, Walvick R, Regatte RR. A method for estimating intracellular sodium concentration and extracellular volume fraction in brain in vivo using sodium magnetic resonance imaging. Sci Rep. 23 avr 2014;4(1):4763. doi:10.1038/srep04763 [doi]
4. Zhang H, Schneider T, Wheeler-Kingshott CA, Alexander DC. NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. NeuroImage. 16 juill 2012;61(4):1000‑16. doi:10.1016/j.neuroimage.2012.03.072 [doi]
5. Asllani I, Madelin G, Bozzali M, Cercignani M. Measurement of Intraneurite Sodium Concentration from NODDI-based Partial Volume Correction of in vivo 23Na MRI.
6. Fonteijn HM, Modat M, Clarkson MJ, et al. An event-based model for disease progression and its application in familial Alzheimer’s disease and Huntington’s disease. NeuroImage. 2012;60(3):1880-1889. doi:10.1016/j.neuroimage.2012.01.062 [doi]
7. Coste A, Boumezbeur F, Vignaud A, et al. Tissue sodium concentration and sodium T1 mapping of the human brain at 3 T using a Variable Flip Angle method. Magn Reson Imaging. 2019;58:116-124. doi:10.1016/j.mri.2019.01.015 [doi]
8. Daducci A, Canales-Rodríguez EJ, Zhang H, Dyrby TB, Alexander DC, Thiran JP. Accelerated Microstructure Imaging via Convex Optimization (AMICO) from diffusion MRI data. NeuroImage. 15 janv 2015;105:32‑44. doi:10.1016/j.neuroimage.2014.10.026 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/405-02-002