567-06-016 Registered Abstract

Examination of Tumor Cell Invasion in the BG5-Glioma Model using MR-Elastography

Primary: Contrast Mechanisms - Elastography

Secondary: Preclinical Animal & in vitro MR - Small Animals

567-06-016 · Novel Contrast Mechanisms II · Wednesday, 13 May, 4:55 PM–5:50 PM · Digital Posters Row H

Keywords: Glioma Brain Tumor Imaging Brain Mechanics Brain MR Elastography Tumor stiffness

Accepted

Hannah E Fels-Palesandro¹, Yannik Streibel¹, Melina Müller^2,3, Kirill Mironov^2,3, Alexander Weiand^2,3, Sophie Heuer^2,3, Strahinja Stojanovic¹, Volker Sturm¹, Manuel Fischer¹, Sabine Heiland¹, Martin Bendszus¹, Ralph Sinkus^4,5, Katharina Schregel^1,6

¹Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany

²Clinical Cooperation Unit Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany

³Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany

⁴Department of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

⁵INSERM U1149 - CRI, University Paris Cité, Paris, France

⁶Department of Radiology, Section of Neuroradiology, Jena University Hospital, Jena, Germany

Presenting Author: Gabrielle Mangin

Synopsis

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References

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2. Ellingson BM, Chung C, Pope WB, Boxerman JL, Kaufmann TJ: Pseudoprogression, radionecrosis, inflammation or true tumor progression? challenges associated with glioblastoma response assessment in an evolving therapeutic landscape. J Neurooncol 2017; 134:495–504.

3. Chang PD, Chow DS, Yang PH, Filippi CG, Lignelli A: Predicting Glioblastoma Recurrence by Early Changes in the Apparent Diffusion Coefficient Value and Signal Intensity on FLAIR Images. Am J Roentgenol 2017; 208:57–65.

4. Muthupillai R, Ehman RL: Magnetic resonance elastography. Nat Med 1996; 2:601–603.

5. Fels-Palesandro H, Heuer S, Boztepe B, et al.: Assessment of Tumor Cell Invasion and Radiotherapy Response in Experimental Glioma by Magnetic Resonance Elastography. J Magn Reson Imaging JMRI 2025; 61:1203–1218.

6. Venkataramani V, Yang Y, Schubert MC, et al.: Glioblastoma hijacks neuronal mechanisms for brain invasion. Cell 2022; 185:2899-2917.e31.

7. Fedorov A, Beichel R, Kalpathy-Cramer J, et al.: 3D Slicer as an image computing platform for the Quantitative Imaging Network. Magn Reson Imaging 2012; 30:1323–1341.

8. Green MA, Bilston LE, Sinkus R: In vivo brain viscoelastic properties measured by magnetic resonance elastography. NMR Biomed 2008; 21:755–764.

9. Sinkus R, Tanter M, Xydeas T, Catheline S, Bercoff J, Fink M: Viscoelastic shear properties of in vivo breast lesions measured by MR elastography. Magn Reson Imaging 2005; 23:159–165.

10. Bender R, Lange S: Adjusting for multiple testing--when and how? J Clin Epidemiol 2001; 54:343–349.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/567-06-016