Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
363-01-010 ISMRM Abstract

Multi-Parametric MRI Reveals Glymphatic Dysfunction Associated with Sleep and Cognitive Impairment in PD Imaging

Primary: Neuro - Parkinson's Disease
Secondary: Diffusion - DWI/DTI/DKI
363-01-010 · Neurological Application of Advanced Diffusion and Quantitative MRI · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row D
Keywords: Parkinson's Disease Glymphatic system
Accepted
Ning Xu1, ZhiPiao Gao1, GeJuan Zhang2, CuiPing Mao1, Guangxu Han3, QiuJuan Zhang 1
1The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
2The Affiliated Hospital of Northwest University, Xi’an No.3 Hospital, China
3GE HealthCare MR Research, Beijing, China
Presenting Author: QiuJuan Zhang

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References

1. Keir LHM, Breen DP (2020) New awakenings: current understanding of sleep dysfunction and its treatment in Parkinson’s disease. J Neurol 267:288–294. https:// doi. org/ 10. 1007/s00415-019-09651-z
2. Zhang Y, Zhang C, He XZ, Li ZH, Meng JC, Mao RT, Li X, Xue R, Gui Q, Zhang GX, Wang LH (2023) Interaction between the glymphatic system and α-synuclein in Parkinson’s disease. Mol Neurobiol 60:2209–2222. https:// doi. org/ 10. 1007/s12035- 023- 03212-2
3. Zou W, Pu T, Feng W, Lu M, Zheng Y, Du R, Xiao M, Hu G(2019) Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein. Transl Neurodegener 8:7. https:// doi. org/ 10. 1186/s40035- 019- 0147-y
4. Huang P, Liu L, Zhang Y, Zhong S, Liu P, Hong H, Wang S, Xie L, Lin M, Jiaerken Y, Luo X, Li K, Zeng Q, Cui L, Li J, Chen Y, Zhang R; Alzheimer's Disease Neuroimaging Initiative. Development and validation of a perivascular space segmentation method in multi-center datasets. Neuroimage. 2024 Sep;298:120803. doi: 10.1016/j.neuroimage.2024.120803. Epub 2024 Aug 23. PMID: 39181194. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/363-01-010