Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
603-01-003 ISMRM Abstract

Associations of white matter hyperintensity regression and progression with cognitive and structural brain changes

Primary: Neuro - Aging
Secondary: Neuro - White Matter
603-01-003 · Dementia Not Related to Alzheimer's Disease · Thursday, 14 May, 8:30 AM–10:20 AM · Auditorium 1
Keywords: White matter hyperintensity regression Brain aging Longitudinal MRI Cognitive decline Brain atrophy
Accepted
Jiajia Zhang 1, Xuejia Jia1, Haibin Li1,2, Xiuqin Jia1,2, Qi Yang1,3,4
1Beijing Chaoyang Hospital, Capital Medical University, beijing, China
2Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
3Key Laboratory of Medical Engineering for Cardiovascular Disease, Ministry of Education, Beijing, China
4Laboratory for Clinical Medicine, Capital Medical University, Beijing, China
Presenting Author: Jiajia Zhang

Synopsis

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References

1. Aging Biomarker Consortium, Jia YJ, Wang J, et al. A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium. Life Medicine. 2023;2(3):lnad017. doi:10.1093/lifemedi/lnad017 [doi]
2. Jochems ACC, Arteaga C, Chappell F, et al. Longitudinal Changes of White Matter Hyperintensities in Sporadic Small Vessel Disease: A Systematic Review and Meta-analysis. Neurology. 2022;99(22):e2454-e2463. doi:10.1212/WNL.0000000000201205 [doi]
3. Jochems ACC, Muñoz Maniega S, Clancy U, et al. Longitudinal Cognitive Changes in Cerebral Small Vessel Disease: The Effect of White Matter Hyperintensity Regression and Progression. Neurology. 2025;104(4):e213323. doi:10.1212/WNL.0000000000213323 [doi]
4. Alfaro-Almagro F, Jenkinson M, Bangerter NK, et al. Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank. NeuroImage. 2018;166:400-424. doi:10.1016/j.neuroimage.2017.10.034 [doi]
5. Kloppenborg RP, Nederkoorn PJ, Geerlings MI, van den Berg E. Presence and progression of white matter hyperintensities and cognition: a meta-analysis. Neurology. 2014;82(23):2127-2138. doi:10.1212/wnl.0000000000000505 [doi]
6. Al-Janabi OM, Bauer CE, Goldstein LB, et al. White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups. Brain Sci. 2019;9(7):170. doi:10.3390/brainsci9070170 [doi]
7. Wardlaw JM, Hernández MCV, Muñoz‐Maniega S. What are White Matter Hyperintensities Made of? Journal of the American Heart Association. Published online June 23, 2015. doi:10.1161/JAHA.114.001140 [doi]

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http://echo.ismrm.org/p/ISMRM2026/603-01-003