367-05-002 ISMRM Abstract

Microstructural profile of multiple sclerosis lesions by combined analysis of QSM and time-dependent diffusion MRI

Primary: Neuro - Multiple Sclerosis

Secondary: Diffusion - Microstructure

367-05-002 · Neuroinflammation: Myelin and Iron · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row H

Keywords: Multiple Sclerosis Quantitative Susceptibility mapping Cognitive impairment Oscillating gradient spin-echo Paramagnetic rim lesions

Accepted

Bohong Zou¹, Sijia Li¹, Xueming Li¹, Chen Zhang², Jie Sun¹, Zhang Zhang¹, Thorsten Feiweier³, Ningnannan Zhang ¹

¹Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China

²MR Research Collaboration, Siemens Healthineers, Beijing, China

³MR Research and Clinical Translation, Siemens Healthineers AG, Erlangen, Germany

Presenting Author: Ningnannan Zhang

Synopsis

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References

1. Montalban X, Lebrun-Frénay C, Oh J, et al. Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria. Lancet Neurol. 2025;24(10):850-865. doi:10.1016/S1474-4422(25)00270-4 [doi]

2. Rahmanzadeh R, Galbusera R, Lu PJ, et al. A New Advanced MRI Biomarker for Remyelinated Lesions in Multiple Sclerosis. Ann Neurol. 2022;92(3):486-502. doi:10.1002/ana.26441 [doi]

3. Su Y, Qiu Y, Huang X, et al. Benign and Malignant Breast Lesions: Differentiation Using Microstructural Metrics Derived from Time-Dependent Diffusion MRI. Radiol Imaging Cancer. 2025;7(3):e240287. doi:10.1148/rycan.240287 [doi]

4. Gillen KM, Mubarak M, Park C, et al. QSM is an imaging biomarker for chronic glial activation in multiple sclerosis lesions. Ann Clin Transl Neurol. 2021;8(4):877-886. doi:10.1002/acn3.51338 [doi]

5. QSM Consensus Organization Committee, Bilgic B, Costagli M, et al. Recommended implementation of quantitative susceptibility mapping for clinical research in the brain: A consensus of the ISMRM electro-magnetic tissue properties study group. Magn Reson Med. 2024;91(5):1834-1862. doi:10.1002/mrm.30006 [doi]

6. Jiang X, Li H, Devan SP, Gore JC, Xu J. MR cell size imaging with temporal diffusion spectroscopy. Magn Reson Imaging. 2021;77:109-123. doi:10.1016/j.mri.2020.12.010 [doi]

7. Cagol A, Benkert P, Melie-Garcia L, et al. Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS. Neurology. 2024;102(1):e207768. doi:10.1212/WNL.0000000000207768 [doi]

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http://echo.ismrm.org/p/ISMRM2026/367-05-002