Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
552-01-008 / 552-01-008 ISMRM Abstract

Longitudinal metabolic and microstructural changes in low-grade gliomas treated with vorasidenib

Accepted
Capucine Cadin 1, Lucia Nichelli1,2, Malgorzata Marjanska3, Mélanie Didier1, Filip Szczepankiewicz4, Markus Nilsson4, Alberto Picca1,2, Caroline Dehais1,2, Bertrand Mathon1,2, Stéphane Lehéricy1,2, Franck Bielle1,2, Marc Sanson1,2, Mehdi Touat1,2, Francesca Branzoli1
1Paris Brain Institute - ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne University, Paris, France
2Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière-Charles-Foix, Paris, France
3Center for Magnetic Resonance Research, Dept. of Radiology, University of Minnesota, Minneapolis, United States of America
4Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden
Presenting Author: Capucine Cadin

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. I. K. Mellinghoff et al., « Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial », Nat Med, vol. 29, no 3, p. 615‑622, mars 2023, doi: 10.1038/s41591-022-02141-2. [doi]
2. A. L. Di Stefano et al., « In Vivo 2-Hydroxyglutarate Monitoring With Edited MR Spectroscopy for the Follow-up of IDH-Mutant Diffuse Gliomas: The IDASPE Prospective Study », Neurology, vol. 100, no 1, p. e94‑e106, janv. 2023, doi: 10.1212/WNL.0000000000201137. [doi]
3. A. R. Molloy et al., « MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma », Theranostics, vol. 10, no 19, p. 8757‑8770, 2020, doi: 10.7150/thno.47317. [doi]
4. O. C. Andronesi et al., « Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate », Nat Commun, vol. 9, no 1, p. 1474, avr. 2018, doi: 10.1038/s41467-018-03905-6. [doi]
5. F. Szczepankiewicz et al., « The link between diffusion MRI and tumor heterogeneity: Mapping cell eccentricity and density by diffusional variance decomposition (DIVIDE) », Neuroimage, vol. 142, p. 522‑532, nov. 2016, doi: 10.1016/j.neuroimage.2016.07.038. [doi]
6. M. Nilsson et al., « Tensor‐valued diffusion MRI in under 3 minutes: an initial survey of microscopic anisotropy and tissue heterogeneity in intracranial tumors », Magn Reson Med, vol. 83, no 2, p. 608‑620, févr. 2020, doi: 10.1002/mrm.27959. [doi]
7. I. K. Mellinghoff et al., « Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma », N Engl J Med, vol. 389, no 7, p. 589‑601, août 2023, doi: 10.1056/NEJMoa2304194. [doi]
8. M. Mescher, H. Merkle, J. Kirsch, M. Garwood, et R. Gruetter, « Simultaneous in vivo spectral editing and water suppression », NMR Biomed, vol. 11, no 6, p. 266‑272, oct. 1998, doi: 10.1002/(sici)1099-1492(199810)11:6<266::aid-nbm530>3.0.co;2-j. [doi]
9. I. Tkác, Z. Starcuk, I. Y. Choi, et R. Gruetter, « In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time », Magn Reson Med, vol. 41, no 4, p. 649‑656, avr. 1999, doi: 10.1002/(sici)1522-2594(199904)41:4<649::aid-mrm2>3.0.co;2-g. [doi]
10. S. W. Provencher, « Estimation of metabolite concentrations from localized in vivo proton NMR spectra », Magn Reson Med, vol. 30, no 6, p. 672‑679, déc. 1993, doi: 10.1002/mrm.1910300604. [doi]
11. F. Szczepankiewicz, J. Sjölund, F. Ståhlberg, J. Lätt, et M. Nilsson, « Tensor-valued diffusion encoding for diffusional variance decomposition (DIVIDE): Technical feasibility in clinical MRI systems », PLoS ONE, vol. 14, no 3, p. e0214238, mars 2019, doi: 10.1371/journal.pone.0214238. [doi]
12. Z. J. Reitman et al., « Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome », Proc Natl Acad Sci U S A, vol. 108, no 8, p. 3270‑3275, févr. 2011, doi: 10.1073/pnas.1019393108. [doi]

Cite this abstract