468-02-013 ISMRM Abstract

Association between skeletal muscle metabolic characteristics and frailty score in patients with type 2 diabetes mellitus

Primary: Musculoskeletal - Muscle

Secondary: Analysis Methods - Data Processing

468-02-013 · Type 2 Diabetes · Tuesday, 12 May, 9:15 AM–10:10 AM · Digital Posters Row I

Keywords: In vivo proton magnetic resonance spectroscopy Type 2 diabetes mellitus Frailty Muscle Metabolism Intramyocellular Lipids

Accepted

Bowen Wang ^1,2, Yunning Luo^1,2, Liping Zuo^1,2, Jinlei Fan^1,2, Jiaxiang xin³, Dexin Yu^1,2

¹Department of Radiology, Qilu Hospital of Shandong University, Jinan, China

²Qilu Medical Imaging Institute of Shandong University, Ji'nan, China

³Magnetic Resonance Research Collaboration, Shanghai, China

Presenting Author: Bowen Wang

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References

1. Chen, K., Zhang, H., Wu, N. et al. Global risk factors, epidemiology, and disease burden of type 2 diabetes. Sci. China Life Sci. (2025). https://doi.org/10.1007/s11427-024-3036-4 [doi]

2. Schlesinger, S., Neuenschwander, M., Barbaresko, J. et al. Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies. Diabetologia 65, 275-285 (2022). https://doi.org/10.1007/s00125-021-05592-3 [doi]

3. Lu, X., Xie, Q., Pan, X. et al. Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy. Sig Transduct Target Ther 9, 262 (2024). https://doi.org/10.1038/s41392-024-01951-9 [doi]

4. Buitinga M, Veeraiah P, Haans F, Schrauwen-Hinderling VB. Ectopic lipid deposition in muscle and liver, quantified by proton magnetic resonance spectroscopy. Obesity (Silver Spring). 2023; 31(10): 2447-2459. https://doi.org/10.1002/oby.23865 [doi]

5. Heerschap A, Houtman C, in ’t Zandt HJA, van den Bergh AJ, Wieringa B. Introduction to in vivo 31P magnetic resonance spectroscopy of (human) skeletal muscle. Proceedings of the Nutrition Society. 1999;58(4):861-870. https://doi.org/10.1017/S0029665199001160 [doi]

6. Ranjana Sinha, Sylvie Dufour, Kitt Falk Petersen, Vincent LeBon, Staffan Enoksson, Yong-Zhan Ma, Mary Savoye, Douglas L. Rothman, Gerald I. Shulman, Sonia Caprio; Assessment of Skeletal Muscle Triglyceride Content by 1H Nuclear Magnetic Resonance Spectroscopy in Lean and Obese Adolescents: Relationships to Insulin Sensitivity, Total Body Fat, and Central Adiposity. Diabetes 1 April 2002; 51 (4): 1022-1027. https://doi.org/10.2337/diabetes.51.4.1022 [doi]

7. E. Schrama, M. Hooijmans, N. van de Velde, E. Niks, H. Kan, and D. Cameron, “ Skeletal Muscle Membrane Permeability Markers Derived From 31P-MRS May Reflect Disease Activity in Becker Muscular Dystrophy,” NMR in Biomedicine 38, no. 11 (2025): e70155, https://doi.org/10.1002/nbm.70155. [doi]

8. Naëgel, A., Viallon, M., Ratiney, H., Nguyen, T., Leporq, B., Kennouche, D., Grenier, T., Grundler, F., Mesnage, R., Guy, J.-M., Schultze, R., Wilhelmi de Toledo, F. and Croisille, P. (2025), Impact of Long-Term Fasting on Skeletal Muscle: Structure, Energy Metabolism and Function Using 31P/1H MRS and MRI. Journal of Cachexia, Sarcopenia and Muscle, 16: e13773. https://doi.org/10.1002/jcsm.13773 [doi]

9. Brennan NA, Fishbein KW, Reiter DA, Ferrucci L and Spencer RG (2021) Contribution of Intramyocellular Lipids to Decreased Computed Tomography Muscle Density With Age. Front. Physiol. 12:632642. https://doi.org/10.3389/fphys.2021.632642 [doi]

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http://echo.ismrm.org/p/ISMRM2026/468-02-013