Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
565-01-011 ISMRM Abstract

Dysfunction of the Brain's Microenvironment in Cognitive Impairment of SLE: A Free Water and DTI-ALPS Study

Primary: Neuro - Neuroinflammation
Secondary: Neuro - Stroke and Cerebrovascular Disorders
565-01-011 · Neuroinflammation: Fluids and Flow · Wednesday, 13 May, 8:20 AM–9:15 AM · Digital Posters Row F
Keywords: Diffusivity along the perivascular spaces 3T MRI Free Water Imaging NPSLE SLE
Accepted
zhaoli zheng 1, Hu Liu1, Xinguang Zhao2, Yueluan Jiang3
1Radiology, The First Hospital of China Medical University, Shenyang, China
2Department of radiology, Fushun Central Hospital,Fushun,CN, China
3MR Research Collaboration Team, Siemens Healthineers Ltd., Beijing, China
Presenting Author: zhaoli zheng

Synopsis

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References

1. Donnellan, C., H. Cohen, and D.J. Werring, Cognitive dysfunction and associated neuroimaging biomarkers in antiphospholipid syndrome: a systematic review. Rheumatology (Oxford), 2021. 61(1): p. 24-41.
2. Panopalis, P., et al., Impact of memory impairment on employment status in persons with systemic lupus erythematosus. Arthritis Rheum, 2007. 57(8): p. 1453-60.
3. Pasternak, O., et al., Free water elimination and mapping from diffusion MRI. Magn Reson Med, 2009. 62(3): p. 717-30.
4. Taoka, T., et al., Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method. Magn Reson Med Sci, 2024. 23(3): p. 268-290.
5. Satpathi, S., et al., Evaluation and interpretation of DTI-ALPS, a proposed surrogate marker for glymphatic clearance, in a large population-based sample. Alzheimers Res Ther, 2025. 17(1): p. 191.
6. Garyfallidis, E., et al., Dipy, a library for the analysis of diffusion MRI data. Front Neuroinform, 2014. 8: p. 8.
7. Nägele, F.L., et al., Longitudinal microstructural alterations surrounding subcortical ischemic stroke lesions detected by free-water imaging. Hum Brain Mapp, 2024. 45(8): p. e26722.
8. Langhein, M., et al., Association between peripheral inflammation and free-water imaging in Major Depressive Disorder before and after ketamine treatment - A pilot study. J Affect Disord, 2022. 314: p. 78-85.
9. Fanouriakis, A., et al., Update οn the diagnosis and management of systemic lupus erythematosus. Ann Rheum Dis, 2021. 80(1): p. 14-25.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/565-01-011