367-01-013 ISMRM Abstract

Detection of Chemotherapy-Induced Glucose Metabolism Alterations in Bladder Cancer Using DMRSI

Primary: Contrast Mechanisms - Deuterium

Secondary: Preclinical Animal & in vitro MR - Small Animals

367-01-013 · Fuel and Function: Metabolism in the Body · Monday, 11 May, 8:20 AM–9:15 AM · Digital Posters Row H

Keywords: Glucose metabolism Bladder cancer Chemotherapy Response Deuterium MRSI

Accepted

Ganghan Yang ^1,2, Lingmin Kong³, Bei Weng³, Zhihua Wen³, Qian Cai³, Qian Wan^1,4, Cuien Zheng¹, Feng Du¹, Yan Guo³, Shiting Feng³, Xin Liu^1,4,5, Ye Li^1,4,5, Huanjun Wang³, Chao Zou^1,4,5

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

²The School of Electronic and Information Engineering, Harbin Institute of Technology, HARBIN, China

³Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, China

⁴Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen, China

⁵State Key Laboratory of Biomedical Imaging Science and System, Shenzhen, China

Presenting Author: Ganghan Yang

Synopsis

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References

1. Witjes JA, Bruins HM, Carrión A, et al. European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines. Eur Urol. 2024;85(1):17–31.

2. Choi SJ, Park KJ, Lee G, et al. Urothelial phase CT for assessment of pathologic complete response after neoadjuvant chemotherapy in muscle-invasive bladder cancer. Eur J Radiol. 2020;126:108902.

3. Warburg O. On respiratory impairment in cancer cells. Science. 1956;124(3215):269–270.

4. De Martino M, Rathmell JC, Galluzzi L, Vanpouille-Box C. Cancer cell metabolism and antitumour immunity. Nat Rev Immunol. 2024;24(9):654–669.

5. De Feyter HM, Behar KL, Corbin ZA, et al. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Sci Adv. 2018;4(8):eaat7314.

6. Low JCM, Cao J, Hesse F, et al. Deuterium Metabolic Imaging Differentiates Glioblastoma Metabolic Subtypes and Detects Early Response to Chemoradiotherapy. Cancer Res. 2024;84(12):1996–2008.

7. von Morze C, Engelbach JA, Blazey T, et al. Comparison of hyperpolarized ¹³C and non-hyperpolarized deuterium MRI approaches for imaging cerebral glucose metabolism. Magn Reson Med. 2021;85(4):1795–1804.

8. Kaggie JD, Khan AS, Matys T, et al. Deuterium metabolic imaging and hyperpolarized 13C-MRI of the normal human brain at clinical field strength reveals differential cerebral metabolism. Neuroimage. 2022;257:119284.

9. Zou C, Ruan Y, Li H, et al. A new deuterium-labeled compound [2,3,4,6,6′-(²H₅)]-D-glucose for deuterium magnetic resonance metabolic imaging. NMR Biomed. 2023;36(7):e4890.

10. Han R, Zhao W, Gu X, Gao X, Yang YG, Zhang X. Different tumorigenicity and distinct metastasis and gene signature between orthotopic and subcutaneous neuroblastoma xenografted mice. Aging (Albany NY). 2022;14(4):1932-1940.

11. Cai Y, Chen T, Liu J, et al. Orthotopic Versus Allotopic Implantation: Comparison of Radiological and Pathological Characteristics. J Magn Reson Imaging. 2022;55(4):1133-1140.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/367-01-013