Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
402-02-003 ISMRM Abstract

Alterations in functional MRI parameters of the fetal kidney associated with preterm delivery

Primary: Body - Kidney
Secondary: Acquisition & Reconstruction
402-02-003 · Inside the Bean: Advances in Renal MRI · Tuesday, 12 May, 8:20 AM–10:10 AM · Hall 1B
Keywords: Fetal MRI Renal Fetal Development T2star relaxometry
Accepted
Charline BRADSHAW1,2, Alena Uus3,4, Molly Dillon2, Anangsha Kumar5, Megan Hall6,7, Srividhya Sankaran2, MARY A RUTHERFORD8,9, Lisa Story6,7,10,11,12, Jana Hutter13,14,15, Kelly Payette 16,17
1Early Life Imaging Research Department, School of Biomedical Engineering & Imaging Sciences, Kings College London, London, United Kingdom
2Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
3Early Life Imaging Research Department, School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom
4Imaging Physics and Engineering Department, School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom
5Department of Women and Children’s Health, King's College London, London, United Kingdom
6Department of Early Life Imaging, School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom
7Women's Health department, School of Life Course and Population Sciences, King's College London, London, United Kingdom
8Research Dept of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
9Imaging Physics and Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
10Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom
11Fetal Medicine, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
12Research department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
13Smart Imaging Lab, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
14Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
15Research Dept of Imaging Physics & Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
16Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
17Center for MR Research, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland
Presenting Author: Kelly Payette

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References

1. da Fonseca EB, Damiao R, Moreira DA. Preterm birth prevention. Best Pract Res Clin Obstet Gynaecol 2020; 69: 40-9.
2. Purisch SE, Gyamfi-Bannerman C. Epidemiology of preterm birth. Semin Perinatol 2017; 41(7): 387-91.
3. Deffrennes S, Rayyan M, Fidlers T, van den Heuvel L, Levtchenko E, Arcolino FO. Impact of preterm birth on kidney health and development. Front Med (Lausanne) 2024; 11: 1363097.
4. Ryan D, Sutherland MR, Flores TJ, Kent AL, Dahlstrom JE, Puelles VG, Bertram JF, McMahon AP, Little MH, Moore L, Black MJ. Development of the human fetal kidney from mid to late gestation in male and female infants. eBioMedicine. 2018 Jan;27:275-283. doi:10.1016/j.ebiom.2017.12.016 [doi]
5. Avena-Zampieri CL, Hutter J, Uus A, et al. Functional MRI assessment of the lungs in fetuses that deliver very Preterm: An MRI pilot study. Eur J Obstet Gynecol Reprod Biol 2024; 293: 106-14.
6. Alena Uus, Tong Zhang , Laurence H Jackson , Thomas A Roberts, Mary A Rutherford, Joseph V Hajnal, Maria Deprez. Deformable Slice-to-Volume Registration for Motion Correction of Fetal Body and Placenta MRI. IEE Trans Med Imaging; 2020
7. Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel L, Hassan S. The role of inflammation and infection in preterm birth. Semin Reprod Med 2007; 25(1): 21-39.
8. Story L, Uus A, Hall M, et al. Functional assessment of brain development in fetuses that subsequently deliver very preterm: An MRI pilot study. Prenat Diagn 2024; 44(1): 49-56.
9. Meersschaert J, Cannie M, De Keyzer F. Fetal MRI demonstrates similar volume evolution but different shapes in the right and left kidneys during gestation. Journal of Pediatric Urology, Volume 3, S64
10. Hall, M., Verdera, J.A., Cromb, D. et al. Placental T2* as a measure of placental function across field strength from 0.55T to 3T. Sci Rep 14, 28594 (2024). https://doi.org/10.1038/s41598-024-77406-6 [doi]
11. Hutter J, Kohli V, Dellschaft N, et al. Dynamics of T2* and deformation in the placenta and myometrium during pre-labour contractions. Sci Rep 2022; 12(1): 18542.
12. Ryan D, Sutherland MR, Flores TJ, et al. Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants. EBioMedicine 2018; 27: 275-83.
13. Khatib NG, Y; Weiner, Z; Paz-Shalom, E; Klorin, G; Sabo, E; Beloosesky, R. 504: Maternal inflammation programs fetal renal development. American Journal of Obstetrics & Gynecology 2017; 216(1): S297 - S8.
14. Seely JC. A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy. J Toxicol Pathol 2017; 30(2): 125-33.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/402-02-003