Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
552-01-011 / 552-01-011 ISMRM Abstract

Frequency and Phase Correction of 2-Hydroxyglutarate-Edited MRS Data

Primary: Contrast Mechanisms - Spectroscopy
Secondary: Neuro - Tumors
552-01-011 · Novel Approaches to Spectroscopy · Wednesday, 13 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2
552-01-011 · Novel Approaches to Spectroscopy · Wednesday, 13 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2
Keywords: Deep learning 2-hydroxyglutarate Frequency and phase correction Magnetic Resonance Spectroscopy Gliomas
Accepted
Christopher J Wu1,2, Anke Henning3,4,5, Jia Guo2,6, Kimberly L Chan 5
1Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, United States of America
2Biomedical Engineering, Columbia University, New York, United States of America
3Advanced Imaging Center/UTSW, United States of America
4Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, United States of America
5University of Texas Southwestern Medical Center, Dallas, United States of America
6Psychiatry, Columbia University, New York, United States of America
Presenting Author: Kimberly L Chan

Synopsis

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References

1. Chan KL, Hapani R, Maher EA, Patel TR, Henning A. TE optimization for J-difference editing of 2-hydroxyglutarate at 3T. Magn Reson Med. 2025;94(4):1363-1376. doi:10.1002/mrm.30561 [doi]
2. Evans CJ, Puts NA, Robson SE, et al. Subtraction artifacts and frequency (mis-)alignment in J-difference GABA editing. J Magn Reson Imaging. 2013;38(4):970-975. doi:10.1002/jmri.23923 [doi]
3. Near J, Edden R, Evans CJ, Paquin R, Harris A, Jezzard P. Frequency and phase drift correction of magnetic resonance spectroscopy data by spectral registration in the time domain. Magn Reson Med. 2015;73(1):44-50. doi:10.1002/mrm.25094 [doi]
4. Mikkelsen M, Tapper S, Near J, Mostofsky SH, Puts NAJ, Edden RAE. Correcting frequency and phase offsets in MRS data using robust spectral registration. NMR Biomed. 2020;33(10):e4368. doi:10.1002/nbm.4368 [doi]
5. Edden RA, Oeltzschner G, Harris AD, et al. Prospective frequency correction for macromolecule-suppressed GABA editing at 3T. J Magn Reson Imaging. 2016;44(6):1474-1482. doi:10.1002/jmri.25304 [doi]
6. Simpson R, Devenyi GA, Jezzard P, Hennessy TJ, Near J. Advanced processing and simulation of MRS data using the FID appliance (FID-A)-An open source, MATLAB-based toolkit. Magn Reson Med. 2017;77(1):23-33. doi:10.1002/mrm.26091 [doi]
7. McHugh FA, Jiang J, Luton H, et al. 2-Hydroxyglutarate magnetic resonance spectroscopy for preoperative IDH molecular profiling - A review of the literature and real-world clinical translation in a busy neurosurgical neuro-oncology unit. J Clin Neurosci. 2025;133:111062. doi:10.1016/j.jocn.2025.111062 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/552-01-011