662-02-007 ISMRM Abstract

A Compact 3D-printed Platform with Self-driven Delivery of Hyperpolarized Xenon for HyperCEST MRI Translation

Primary: Physics & Engineering - Phantoms

Secondary: Contrast Mechanisms - Hyperpolarized MR (Gas)

662-02-007 · Advances in Chemical Exchange MRI: CEST, APT, and NOE II · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row C

Keywords: Molecular Imaging Novel Contrast Mechanisms 3D-Printing Xenon HyperCEST

Accepted

Samuel Lehr ^1,2, Patrick Werner^2,3, Jabadurai Jayapaul^2,4, Sebastian K Winkler^1,2, Luca Kempny^1,2, Alexandra Lipka^2,5, Leif Schröder^1,2,4

¹Department of Physics and Astronomy, Ruprecht Karls University Heidelberg, Heidelberg, Germany

²Division of Translational Molecular Imaging, German Cancer Research Center (DKFZ), Heidelberg, Germany

³Department of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

⁴Core Center Heidelberg, German Cancer Consortium (DKTK), Heidelberg, Germany

⁵Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Presenting Author: Samuel Lehr

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References

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3. Hane, F. T., Li, T., Smylie, P., Pellizzari, R. M., Plata, J. A., DeBoef, B., & Albert, M. S.; In vivo detection of cucurbit[6]uril, a hyperpolarized xenon contrast agent for a xenon magnetic resonance imaging biosensor. Scientific Reports 2017, 7(1); doi:10.1038/srep41027 [doi]

4. McHugh, C. T., Kelley, M., Bryden, N. J., & Branca, R. T.; In vivo hyperCEST imaging: Experimental considerations for a reliable contrast. Magnetic Resonance in Medicine 2021, 87(3), 1480–1489; doi:10.1002/mrm.29032 [doi]

5. Kern, A. L., Gutberlet, M., Rumpel, R., Bruesch, I., Hohlfeld, J. M., Wacker, F., & Hensen, B.; Compartment-specific 129Xe HyperCEST z spectroscopy and chemical shift imaging of cucurbit[6]uril in spontaneously breathing rats. Zeitschrift Für Medizinische Physik 2025, 35(1), 33-45; doi:10.1016/j.zemedi.2023.08.005 [doi]

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7. Rose, H. M., Witte, C., Rossella, F., Klippel, S., Freund, C., & Schröder, L.; Development of an antibody-based, modular biosensor for129Xe NMR molecular imaging of cells at nanomolar concentrations. Proceedings of the National Academy of Sciences 2014, 111(32), 11697–11702.; doi:10.1073/pnas.1406797111 [doi]

8. Berthault, P., Boutin, C., Martineau-Corcos, C., & Carret, G.; Use of dissolved hyperpolarized species in NMR: Practical considerations. Progress in Nuclear Magnetic Resonance Spectroscopy 2020, 118–119, 74–90; doi:10.1016/j.pnmrs.2020.03.002 [doi]

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