Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
668-04-006 ISMRM Abstract

Ultra-High Gradient MR Cytometry Enables Non-Invasive Quantification of HCC Microstructure and Aggressiveness

Primary: Diffusion - Microstructure
Secondary: Body - Liver
668-04-006 · Pulse Sequences: Design and Optimization · Thursday, 14 May, 2:35 PM–3:30 PM · Digital Posters Row I
Keywords: Hepatocellular carcinoma MR cytometry
Accepted
Beixuan Zheng1, Diwei Shi2,3, Caixia Fu4, Yishi Wang5, Yilan Ji6, Fan Liu7, Mengsu Zeng1, Hua Guo 7, Ruofan Sheng1
1Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China
2Research Institute of Tsinghua University in Shenzhen, China
3Tsinghua Shenzhen International Graduate School, Tsinghua University, Beijing, China
4MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China
5Research Collaboration Team, Siemens Healthineers, Beijing, China
6Beijing National Day School, Beijing, China
7Tsinghua University, Beijing, China
Presenting Author: Hua Guo

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References

1. Shinkawa H, Tanaka S, Kabata D et al (2021) The Prognostic Impact of Tumor Differentiation on Recurrence and Survival after Resection of Hepatocellular Carcinoma Is Dependent on Tumor Size. Liver Cancer 10:461-472 doi:10.1159/000517992. [doi]
2. Schmilovitz-Weiss H, Tobar A, Halpern M, Levy I, Shabtai E, Ben-Ari Z (2011) Tissue expression of squamous cellular carcinoma antigen and Ki67 in hepatocellular carcinoma-correlation with prognosis: a historical prospective study. Diagn Pathol 6:121 doi: 10.1186/1746-1596-6-121. [doi]
3. Xu J, Jiang X, Li H et al (2020) Magnetic resonance imaging of mean cell size in human breast tumors. Magn Reson Med 83:2002-2014 doi: 10.1002/mrm.28056. [doi]
4. Jiang X, Devan SP, Xie J, Gore JC, Xu J (2022) Improving MR cell size imaging by inclusion of transcytolemmal water exchange. NMR Biomed 35:e4799 doi: 10.1002/nbm.4799. [doi]
5. Shi D, Wang X, Li S et al (2025) Comprehensive characterization of tumor therapeutic response via simultaneous mapping of cell size, density, and transcytolemmal water exchange. Magn Reson Imaging 122:110433 doi: 10.1016/j.mri.2025.110433. [doi]
6. Xu J, Does MD, Gore JC (2009) Quantitative characterization of tissue microstructure with temporal diffusion spectroscopy. J Magn Reson 200:189-197 doi: 10.1016/j.jmr.2009.06.022. [doi]
7. Jiang X, Li H, Devan SP, Gore JC, Xu J (2021) MR cell size imaging with temporal diffusion spectroscopy. Magn Reson Imaging 77:109-123 doi: 10.1016/j.mri.2020.12.010. [doi]
8. Fan Q, Eichner C, Afzali M et al (2022) Mapping the human connectome using diffusion MRI at 300 mT/m gradient strength: Methodological advances and scientific impact. Neuroimage 254:118958 doi: 10.1016/j.neuroimage.2022.118958. [doi]

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http://echo.ismrm.org/p/ISMRM2026/668-04-006