Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
665-04-003 ISMRM Abstract

Integrated MRS-NMR Profiling Reveals Brain-Body Metabolic Disruptions in Buprenorphine-Maintained Opioid Dependent Patients

Primary: Neuro - Psychiatric Disorders
Secondary: Preclinical Animal & in vitro MR - Biomarkers
665-04-003 · MR in Organoid/Phantom/Plant/Serum · Thursday, 14 May, 2:35 PM–3:30 PM · Digital Posters Row F
Keywords: 1H MRS Metabolomics Metabolic biomarker Buprenorphine maintenance treatment Opioid dependence
Accepted
Nisha Chauhan 1, Anju Dhawan2, Biswadip Chatterjee2, Siddharth Sarkar2, Mani Kalaivani3, S Senthil Kumaran1
1Department of Nuclear Magnetic Resonance (NMR), All India Institute of Medical Sciences, New Delhi, India
2National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences, New Delhi, India
3Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India
Presenting Author: Nisha Chauhan

Synopsis

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References

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2. Mahboub N, Rizk R, Karavetian M, de Vries N. Nutritional status and eating habits of people who use drugs and/or are undergoing treatment for recovery: a narrative review. Nutr Rev. 2021;79(6):627-635. doi:10.1093/nutrit/nuaa095 [doi]
3. Henigsberg N, Šarac H, Radoš M, et al. Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NAA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study. Front Psychiatry. 2017;8:277. doi:10.3389/fpsyt.2017.00277 [doi]
4. Yue Q, Liu M, Nie X, et al. Quantitative 3.0T MR spectroscopy reveals decreased creatine concentration in the dorsolateral prefrontal cortex of patients with social anxiety disorder. PLoS One. 2012;7(10):e48105. doi:10.1371/journal.pone.0048105 [doi]
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6. Simon L, Jolley SE, Molina PE. Alcoholic Myopathy: Pathophysiologic Mechanisms and Clinical Implications. Alcohol Res. 2017;38(2):207-217.
7. Sookoian S, Pirola CJ. Alanine and aspartate aminotransferase and glutamine-cycling pathway: their roles in pathogenesis of metabolic syndrome. World J Gastroenterol. 2012;18(29):3775-3781. doi:10.3748/wjg.v18.i29.3775 [doi]
8. Concerto C, Chiarenza C, Di Francesco A, et al. Neurobiology and Applications of Inositol in Psychiatry: A Narrative Review. Curr Issues Mol Biol. 2023;45(2):1762-1778. doi:10.3390/cimb45020113 [doi]
9. Caspani G, Zuberi A, Neugebauer LA, et al. Metabolic phenotyping of opioid and psychostimulant misuse: human and animal studies. Br J Pharmacol. 2022;179(2):267-292.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/665-04-003