666-03-016 ISMRM Abstract

Quantitative MRI of Delipidation in Human Brain Samples

Primary: Preclinical Animal & in vitro MR - Biomarkers

Secondary: Acquisition & Reconstruction - Quantitative Imaging: relaxometry, multi-parametric, MR Fingerprinting, and synthetic MRI

666-03-016 · Neuro-Biomarkers · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row G

Keywords: Ultra-short Echo Time (UTE) Magnetisation Transfer Imaging T1rho and T2 mapping Myelin proton fraction DELIPIDATION

Accepted

Jiayang Wu^1,2, Sarah Tang², James Lo², Xin Cheng², Jiang Du^2,3, Yajun Ma²

¹Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China

²University of California, Berkeley, United States of America

³Radiology Service, VA San Diego Healthcare System, La Jolla, California, San Diego, United States of America

Presenting Author: Soo Hyun Shin

Synopsis

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References

1. Koenig SH, Brown RD, Spiller M, Lundbom N. Relaxometry of brain: why WM appears bright in MRI. Magn Reson Med. 1990;14(3):482-495. doi:10.1002/mrm.1910140306 [doi]

2. MacKay A, Whittall K, Adler J, Li D, Paty D, Graeb D. In vivo visualization of myelin water in brain by magnetic resonance. Magn Reson Med. 1994;31(6):673-677. doi:10.1002/mrm.1910310614 [doi]

3. Yarnykh VL. Fast macromolecular proton fraction mapping from a single off-resonance magnetization transfer measurement. Magn Reson Med. 2012;68(1):166-178. doi:10.1002/mrm.23224 [doi]

4. Ma YJ, Jang H, Wei Z, et al. Myelin Imaging in Human Brain Using a Short Repetition Time Adiabatic Inversion Recovery Prepared Ultrashort Echo Time (STAIR-UTE) MRI Sequence in Multiple Sclerosis. Radiology. 2020;297(2):392-404. doi:10.1148/radiol.2020200425 [doi]

5. Ma YJ, Searleman AC, Jang H, et al. Whole-Brain Myelin Imaging Using 3D Double-Echo Sliding Inversion Recovery Ultrashort Echo Time (DESIRE UTE) MRI. Radiology. 2020;294(2):362-374. doi:10.1148/radiol.2019190911 [doi]

6. Tainaka K, Murakami TC, Susaki EA, et al. Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents. Cell Rep. 2018;24(8):2196-2210.e9. doi:10.1016/j.celrep.2018.07.056 [doi]

7. Ma YJ, Zhao W, Wan L, et al. Whole knee joint T1 values measured in vivo at 3T by combined 3D ultrashort echo time cones actual flip angle and variable flip angle methods. Magn Reson Med. 2019;81(3):1634-1644. doi:10.1002/mrm.27510 [doi]

8. Lo J, Du K, Lee D, et al. Multicompartment imaging of the brain using a comprehensive MR imaging protocol. Neuroimage. 2024;298:120800. doi:10.1016/j.neuroimage.2024.120800 [doi]

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http://echo.ismrm.org/p/ISMRM2026/666-03-016