Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
660-03-009 ISMRM Abstract

Molecular MRI Biomarker Development for the Early Diagnosis of Alzheimer’s Disease

Primary: Neuro - Alzheimer's Disease
Secondary: Contrast Mechanisms - CEST / APT / NOE
660-03-009 · Advances in Chemical Exchange MRI: CEST, APT, and NOE I · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row A
Keywords: Alzheimer's Disease CEST / APT / NOE Magnetic Resonance Imaging (MRI) Amide proton transfe weighted imaging Amide proton transfer
Accepted
Zongpai Zhang 1, Jingpu Wu1,2, Isabel M Rios Pulgar3, Keyi Chai1,2, Puyang Wang1, Shanshan Jiang1, Arnold Bakker3,4, Jinyuan Zhou1
1Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States of America
2Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, United States of America
3Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, United States of America
4Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
Presenting Author: Zongpai Zhang

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References

1. Thal, D.R., et al., Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer’s disease. Acta neuropathologica, 2015. 129(2): p. 167-182.
2. Penke, B., M. Szűcs, and F. Bogár, Oligomerization and conformational change turn monomeric β-amyloid and tau proteins toxic: Their role in Alzheimer’s pathogenesis. Molecules, 2020. 25(7): p. 1659.
3. Chen, X.-Q. and W.C. Mobley, Alzheimer disease pathogenesis: insights from molecular and cellular biology studies of oligomeric Aβ and tau species. Frontiers in Neuroscience, 2019. 13: p. 659.
4. Ferreira, S.T., M.N. Vieira, and F.G. De Felice, Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases. IUBMB life, 2007. 59(4‐5): p. 332-345.
5. Li, C., et al., Amide proton transfer imaging of Alzheimer's disease and Parkinson's disease. Magnetic Resonance Letters, 2023. 3(1): p. 22-30.
6. Zhou, J., et al., APT‐weighted MRI: techniques, current neuro applications, and challenging issues. Journal of Magnetic Resonance Imaging, 2019. 50(2): p. 347-364.
7. Wu, J., et al., Robust Extrapolated Semi‐Solid Magnetization Transfer Reference Fitting for Quantitative Amide Proton Transfer Imaging at 3 T: Application to Patients With Mild Cognitive Impairment and Mild Dementia. Magnetic Resonance in Medicine, 2025. DOI: 10.1002/mrm.70122. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/660-03-009