Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
662-03-009 ISMRM Abstract

Multiparametric Histogram Analysis for the Differentiation of IDH-mutant grade-4 Astrocytomas from IDH-wild-type Glioblastoma

Primary: Neuro - Tumors
Secondary: Analysis Methods - Classification and Prediction
662-03-009 · Classification: Other Cancer · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row C
Keywords: Diffusion Tensor Imaging Glioma classification Glioblastomas IDH-mutant astrocytoma. DSC-MRI
Accepted
Archith Rajan 1, Nishanth Suri2, Ajay Kumar1, Stephen Bagley3, Richard Phillips4, Lisa Desiderio1, Steven Brem5, Laurie Loevner1, Suyash Mohan1, Sanjeev Chawla1
1Department of Radiology, Division of Neuroradiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
2Department of Biomedical Engineering Science and Health Systems, Drexel University, Philadelphia, United States of America
3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
4University of Pennsylvania, Philadelphia, United States of America
5Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
Presenting Author: Archith Rajan

Synopsis

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References

1. Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. New Eng J Med. 2009 Feb 19;360(8):765-73.PMID: 19228619 [pmid]
2. Andronesi OC, Rapalino O, Gerstner E, et al. Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate. J Clin Invest. 2013 Sep;123(9):3659-63.PMID: 23999439 [pmid]
3. An Z, Tiwari V, Baxter J, et al. 3D high-resolution imaging of 2-hydroxyglutarate in glioma patients using DRAG-EPSI at 3T in vivo. Magn Reson Med. 2019 Feb;81(2):795-802.PMID: 30277274 [pmid]
4. Verma G, Mohan S, Nasrallah MP, et al. Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla. J Transl Med. 2016 Sep 22;14(1):274-82.PMID: 27659543 [pmid]
5. Ichimura K, Pearson DM, Kocialkowski S, et al. IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas. Neuro Oncol. 2009 Aug;11(4):341-7.PMID: 19435942 [pmid]
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7. Xing Z, Yang X, She D, et al. Noninvasive Assessment of IDH Mutational Status in World Health Organization Grade II and III Astrocytomas Using DWI and DSC-PWI Combined with Conventional MR Imaging. Am J Neuroradiol. 2017 Jun;38(6):1138-44.PMID: 28450436 [pmid]
8. Emblem, K.E., Nedregaard, B. et al. 2008. Glioma grading by using histogram analysis of blood volume heterogeneity from MR-derived cerebral blood volume maps. Radiology, 247(3), pp.808-817.PMID: 18487536 [pmid]
9. Law, M., Young, R., et al. 2007. Histogram analysis versus region of interest analysis of dynamic susceptibility contrast perfusion MR imaging data in the grading of cerebral gliomas. American Journal of Neuroradiology, 28(4), pp.761-766.PMID: 17416835 [pmid]
10. Just, N., 2014. Improving tumour heterogeneity MRI assessment with histograms. British journal of cancer, 111(12), pp.2205-2213.PMID: 25268373 [pmid]
11. Wang S, Kim S, Chawla S, et al. Differentiation between glioblastomas and solitary brain metastases using diffusion tensor imaging. NeuroImage. 2009;44:653-60.PMID: 18951985 [pmid]
12. Chawla S, Wang S, Mohan S, et al. Differentiation of brain infection from necrotic glioblastoma using combined analysis of diffusion and perfusion MRI. J Magn Reson Imaging. 2019 Jan;49(1):184-94.PMID: 29676844 [pmid]
13. Wang S, Kim S, Zhang Y, et al. Determination of grade and subtype of meningiomas by using histogram analysis of diffusion-tensor imaging metrics. Radiology. 2012; 262:584-92.PMID: 22084207 [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/662-03-009