663-03-009 ISMRM Abstract

Reliability of T1-weighted Intrathecal Contrast-Enhanced Images and Repeatability of T1 mapping in Brain Tissue and CSF

Primary: Neuro - Neurofluids

Secondary: Contrast Mechanisms - Relaxometry

663-03-009 · Glymphatic System Imaging: From Neurofluid Transport to Neurodegeneration · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row D

Keywords: Glymphatics T1 Mapping Cerebrospinal fluid Brain clearance Intrathecal contrast-enhanced MRI

Accepted

Ingrid Mossige ^1,2,3, Siri F Svensson^2,3, Jørgen Riseth^4,5, Sofie L Lian^1,6, Grethe Løvland⁷, Geir Ringstad^1,3,8,9, Tryggve H Storås^1,2,3, Kaja Nordengen^1,6

¹Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

²Division of Radiology and Nuclear Medicine, Department of Physics and Computational Radiology, Oslo University Hospital, Oslo, Norway

³K.G. Jebsen Center for Brain Fluid Research, University of Oslo, Oslo, Norway

⁴Department of scientific computing and numerical analysis, Simula Research Laboratory, Oslo, Norway

⁵Department of Mathematics, University of Oslo, Oslo, Norway

⁶Department of Neurology, Oslo University Hospital, Oslo, Norway

⁷The Intervention Center, Oslo University Hospital, Oslo, Norway

⁸Department of Radiology, Oslo University Hospital – Rikshospitalet, Oslo, Norway

⁹Department of Geriatrics and Internal Medicine, Soerlandet Hospital, Arendal, Norway

Presenting Author: Ingrid Mossige

Synopsis

Motivation:

Goals:

Approach:

Results:

Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

References

1. Ringstad G, Valnes LM, Dale AM, et al. Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. JCI insight. 2018;3(13). doi:10.1172/jci.insight.121537 [doi]

2. van Osch MJP, Wåhlin A, Scheyhing P, et al. Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood. NMR in Biomedicine. 2024;37(9):e5159. doi:10.1002/nbm.5159 [doi]

3. Ringstad G, Valnes LM, Vatnehol SAS, Pripp AH, Eide PK. Prospective T1 mapping to assess gadolinium retention in brain after intrathecal gadobutrol. Neuroradiology. July 2023. doi:10.1007/s00234-023-03198-7 [doi]

4. Storås TH, Lian SL, Mossige I, et al. T2-weighted T1 mapping and automated segmentation of CSF: Assessment of solute gradients in the healthy brain. July 2025:2025.07.19.25331835. doi:10.1101/2025.07.19.25331835 [doi]

5. Riseth JN, Koch T, Lian SL, et al. Human brain MRI data of CSF tracer evolution over 72h for data-integrated simulations. July 2025:2025.07.23.25331971. doi:10.1101/2025.07.23.25331971 [doi]

6. Boudreau M, Karakuzu A, Cohen-Adad J, et al. Repeat it without me: Crowdsourcing the T1 mapping common ground via the ISMRM reproducibility challenge. Magnetic Resonance in Medicine. 2024;92(3):1115-1127. doi:10.1002/mrm.30111 [doi]

7. Jiang D, Gou Y, Wei Z, Hou X, Yedavalli V, Lu H. Quantification of T1 and T2 of subarachnoid CSF: Implications for water exchange between CSF and brain tissues. Magnetic Resonance in Medicine. 2023;90(6):2411-2419. doi:10.1002/mrm.29829 [doi]

8. Li Z, Xu X, Yang Y, Feng L. Repeatability and Robustness of MP-GRASP T1 Mapping. Magn Reson Med. 2022;87(5):2271-2286. doi:10.1002/mrm.29131 [doi]

9. Szomolanyi P, Rohrer M, Frenzel T, et al. Comparison of the Relaxivities of Macrocyclic Gadolinium-Based Contrast Agents in Human Plasma at 1.5, 3, and 7 T, and Blood at 3 T. Invest Radiol. 2019;54(9):559-564. doi:10.1097/RLI.0000000000000577 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/663-03-009