Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
662-02-011 ISMRM Abstract

CrCEST Measures OXPHOS Improvement and Creatine Decrease following GLP-1 induced weight loss at 7T with 1H-MRS

Primary: Musculoskeletal - Muscle
Secondary: Contrast Mechanisms - CEST / APT / NOE
662-02-011 · Advances in Chemical Exchange MRI: CEST, APT, and NOE II · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row C
Keywords: Obesity Creatine CEST MRI Weight-loss Muscle Metabolism
Accepted
Ryan Armbruster1, neil wilson1,2,3,4, Yvette Frimpong3, Anne R Cappola5, Anastassia Amaro5, Ravinder Reddy1,2,3,4,6
1Department of Radiology, University of Pennsylvania, Philadelphia, United States of America
2Center for Advanced Metabolic Imaging in Precision Medicine, Philadelphia, United States of America
3University of Pennsylvania, Philadelphia, United States of America
4Center for Advanced Metabolic Imaging in Precision Medicine, University of Pennsylvania, Philadelphia, United States of America
5Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania, Philadelphia, United States of America
6Center for Advanced Metabolic Imaging in Precision Medicine, Center for Advanced Metabolic Imaging in Precision Medicine, Philadelphia, United States of America
Presenting Author: Ari Borthakur

Synopsis

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References

1. Conte, C., Hall, K. D. & Klein, S. Is Weight Loss–Induced Muscle Mass Loss Clinically Relevant? JAMA 332, 9 (2024).
2. Armbruster, R. R. et al. Personalized and muscle-specific OXPHOS measurement with integrated CrCEST MRI and proton MR spectroscopy. Nat. Commun. 15, 5387 (2024).
3. Kumar, D. et al. Recovery kinetics of creatine in mild plantar flexion exercise using 3D creatine CEST imaging at 7 Tesla. Magn. Reson. Med. 85, 802–817 (2021).
4. Kogan, F. et al. Method for high-resolution imaging of creatine in vivo using chemical exchange saturation transfer. Magn. Reson. Med. 71, 164–172 (2014).
5. Kim, M., Gillen, J., Landman, B. A., Zhou, J. & Van Zijl, P. C. M. Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments: Water Shift Referencing for CEST Imaging. Magn. Reson. Med. 61, 1441–1450 (2009).
6. Berglund, J., Johansson, L., Ahlström, H. & Kullberg, J. Three‐point dixon method enables whole‐body water and fat imaging of obese subjects. Magn. Reson. Med. 63, 1659–1668 (2010).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/662-02-011