Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-03-005 ISMRM Abstract

Altered Structural-Functional Coupling in Post-Traumatic Stress Disorder are Associated with Neurobiological Profiles

Accepted
Yujie Song 1,2,3, Bin Guo2,4, Bin Huang5, Qiyong Gong2,3,6,7
1Department of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. Address: No.1, Shuaifuyuan, Dongcheng District, Beijing 100730, China
2Xiamen Key Laboratory of Psychoradiology and Neuromodulation, Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, China
3Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China
4Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China
5Department of Radiology, Affiliated Hospital of Guizhou Medical University, Guiyang, China
6Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China
7Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University. Chengdu, Sichuan,China., China
Presenting Author: Yujie Song

Synopsis

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References

1. Schincariol A, Orrù G, Otgaar H, Sartori G, Scarpazza C. Posttraumatic stress disorder (PTSD) prevalence: an umbrella review. Psychol Med. 2024;54(15):1-14. doi:10.1017/S0033291724002319 [doi]
2. Lei D, Li K, Li L, et al. Disrupted Functional Brain Connectome in Patients with Posttraumatic Stress Disorder. Radiology. 2015;276(3):818-827. doi:10.1148/radiol.15141700 [doi]
3. Kearney BE, Lanius RA. Why reliving is not remembering and the unique neurobiological representation of traumatic memory. Nat Ment Health. 2024;2(10):1142-1151. doi:10.1038/s44220-024-00324-z [doi]
4. O’Doherty DCM, Ryder W, Paquola C, et al. White matter integrity alterations in post-traumatic stress disorder. Hum Brain Mapp. 2018;39(3):1327-1338. doi:10.1002/hbm.23920 [doi]
5. Dennis EL, Disner SG, Fani N, et al. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium. Mol Psychiatry. 2021;26(8):4315-4330. doi:10.1038/s41380-019-0631-x [doi]
6. Mount CW, Monje M. Wrapped to Adapt: Experience-Dependent Myelination. Neuron. 2017;95(4):743-756. doi:10.1016/j.neuron.2017.07.009 [doi]
7. Baum GL, Cui Z, Roalf DR, et al. Development of structure–function coupling in human brain networks during youth. Proc Natl Acad Sci. 2020;117(1):771-778. doi:10.1073/pnas.1912034117 [doi]
8. Zhang Z, Liao W, Chen H, et al. Altered functional-structural coupling of large-scale brain networks in idiopathic generalized epilepsy. Brain. 2011;134(Pt 10):2912-2928. doi:10.1093/brain/awr223 [doi]
9. Zarkali A, McColgan P, Leyland LA, Lees AJ, Rees G, Weil RS. Organisational and neuromodulatory underpinnings of structural-functional connectivity decoupling in patients with Parkinson’s disease. Commun Biol. 2021;4(1):86. doi:10.1038/s42003-020-01622-9 [doi]
10. Collin G, Scholtens LH, Kahn RS, Hillegers MHJ, van den Heuvel MP. Affected Anatomical Rich Club and Structural-Functional Coupling in Young Offspring of Schizophrenia and Bipolar Disorder Patients. Biol Psychiatry. 2017;82(10):746-755. doi:10.1016/j.biopsych.2017.06.013 [doi]
11. Jiang Y, Duan M, Li X, et al. Function-structure coupling: White matter functional magnetic resonance imaging hyper-activation associates with structural integrity reductions in schizophrenia. Hum Brain Mapp. 2021;42(12):4022-4034. doi:10.1002/hbm.25536 [doi]
12. Arnatkeviciute A, Fulcher BD, Oldham S, et al. Genetic influences on hub connectivity of the human connectome. Nat Commun. 2021;12(1):4237. doi:10.1038/s41467-021-24306-2 [doi]
13. Allen NJ, Lyons DA. Glia as architects of central nervous system formation and function. Science. 2018;362(6411):181-185. doi:10.1126/science.aat0473 [doi]
14. Zilles K, Palomero-Gallagher N. Multiple Transmitter Receptors in Regions and Layers of the Human Cerebral Cortex. Front Neuroanat. 2017;11:78. doi:10.3389/fnana.2017.00078 [doi]
15. Wang XJ. Macroscopic gradients of synaptic excitation and inhibition in the neocortex. Nat Rev Neurosci. 2020;21(3):169-178. doi:10.1038/s41583-020-0262-x [doi]
16. Esteban O, Markiewicz CJ, Blair RW, et al. fMRIPrep: a robust preprocessing pipeline for functional MRI. Nat Methods. 2019;16(1):111-116. doi:10.1038/s41592-018-0235-4 [doi]
17. Cieslak M, Cook PA, He X, et al. QSIPrep: an integrative platform for preprocessing and reconstructing diffusion MRI data. Nat Methods. 2021;18(7):775-778. doi:10.1038/s41592-021-01185-5 [doi]
18. Schaefer A, Kong R, Gordon EM, et al. Local-Global Parcellation of the Human Cerebral Cortex from Intrinsic Functional Connectivity MRI. Cereb Cortex. 2018;28(9):3095-3114. doi:10.1093/cercor/bhx179 [doi]
19. Najdenovska E, Alemán-Gómez Y, Battistella G, et al. In-vivo probabilistic atlas of human thalamic nuclei based on diffusion- weighted magnetic resonance imaging. Sci Data. 2018;5:180270. doi:10.1038/sdata.2018.270 [doi]
20. Pauli WM, Nili AN, Tyszka JM. A high-resolution probabilistic in vivo atlas of human subcortical brain nuclei. Sci Data. 2018;5:180063. doi:10.1038/sdata.2018.63 [doi]
21. King M, Hernandez-Castillo CR, Poldrack RA, Ivry RB, Diedrichsen J. Functional boundaries in the human cerebellum revealed by a multi-domain task battery. Nat Neurosci. 2019;22(8):1371-1378. doi:10.1038/s41593-019-0436-x [doi]
22. Yang Y, Zheng Z, Liu L, et al. Enhanced brain structure-function tethering in transmodal cortex revealed by high-frequency eigenmodes. Nat Commun. 2023;14(1):6744. doi:10.1038/s41467-023-42053-4 [doi]
23. Facca M, Del Felice A, Bertoldo A. Multiscale and multimodal signatures of structure-function coupling variability across the human neocortex. NeuroImage. 2024;302:120902. doi:10.1016/j.neuroimage.2024.120902 [doi]
24. Dukart J, Holiga S, Rullmann M, et al. JuSpace: A tool for spatial correlation analyses of magnetic resonance imaging data with nuclear imaging derived neurotransmitter maps. Hum Brain Mapp. 2021;42(3):555-566. doi:10.1002/hbm.25244 [doi]
25. Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 2012;489(7416):391-399. doi:10.1038/nature11405 [doi]
26. Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. Omics. 2012;16(5):284-287. doi:10.1089/omi.2011.0118 [doi]
27. Vázquez-Rodríguez B, Suárez LE, Markello RD, et al. Gradients of structure-function tethering across neocortex. Proc Natl Acad Sci U S A. 2019;116(42):21219-21227. doi:10.1073/pnas.1903403116 [doi]
28. Preti MG, Van De Ville D. Decoupling of brain function from structure reveals regional behavioral specialization in humans. Nat Commun. 2019;10(1):4747. doi:10.1038/s41467-019-12765-7 [doi]
29. Patriat R, Birn RM, Keding TJ, Herringa RJ. Default-Mode Network Abnormalities in Pediatric Posttraumatic Stress Disorder. J Am Acad Child Adolesc Psychiatry. 2016;55(4):319-327. doi:10.1016/j.jaac.2016.01.010 [doi]
30. Berg H, Ma Y, Rueter A, et al. Salience and central executive networks track overgeneralization of conditioned-fear in post-traumatic stress disorder. Psychol Med. 2021;51(15):2610-2619. doi:10.1017/S0033291720001166 [doi]
31. Venkataraman A, Dias BG. Expanding the canon: An inclusive neurobiology of thalamic and subthalamic fear circuits. Neuropharmacology. 2023;226:109380. doi:10.1016/j.neuropharm.2022.109380 [doi]
32. Iyadurai L, Blackwell SE, Meiser-Stedman R, et al. Preventing intrusive memories after trauma via a brief intervention involving Tetris computer game play in the emergency department: a proof-of-concept randomized controlled trial. Mol Psychiatry. 2018;23(3):674-682. doi:10.1038/mp.2017.23 [doi]
33. Esterman M, Stumps A, Jagger-Rickels A, et al. Evaluating the evidence for a neuroimaging subtype of posttraumatic stress disorder. Sci Transl Med. 2020;12(568):eaaz9343. doi:10.1126/scitranslmed.aaz9343 [doi]
34. He M, Zhu H, Wang X, Zhou L, Zhang J. Mapping PTSD-Related Brain Dysregulation With Connectome Gradient Analysis. J Magn Reson Imaging. Published online May 24, 2025. doi:10.1002/jmri.29829 [doi]
35. Luppi AI, Mediano PAM, Rosas FE, et al. A synergistic core for human brain evolution and cognition. Nat Neurosci. 2022;25(6):771-782. doi:10.1038/s41593-022-01070-0 [doi]
36. Hänisch B, Hansen JY, Bernhardt BC, et al. Cerebral chemoarchitecture shares organizational traits with brain structure and function. eLife. 2023;12:e83843. doi:10.7554/eLife.83843 [doi]
37. Jiang L, Genon S, Ye J, et al. Gene transcription, neurotransmitter, and neurocognition signatures of brain structural-functional coupling variability. Nat Commun. 2025;16:7623. doi:10.1038/s41467-025-63000-5 [doi]
38. Zannas AS, Provençal N, Binder EB. Epigenetics of Posttraumatic Stress Disorder: Current Evidence, Challenges, and Future Directions. Biol Psychiatry. 2015;78(5):327-335. doi:10.1016/j.biopsych.2015.04.003 [doi]
39. Udeh-Momoh CT, Migeot J, Blackmon K, et al. Resilience and brain health in global populations. Nat Med. 2025;31(8):2518-2531. doi:10.1038/s41591-025-03846-w [doi]

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