Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
562-05-014 ISMRM Abstract

GABA Measurements with and without Macromolecule Suppression in the Neonatal Brain

Primary: Pediatrics - Neuro
Secondary: Pediatrics - Neonatal
562-05-014 · Fetal and Neonatal Imaging · Wednesday, 13 May, 4:00 PM–4:55 PM · Digital Posters Row C
Keywords: Gamma-aminobutyric acid 1H MRS Macromolecules Neonatal brain imaging MEGA-PRESS
Accepted
Steve C Hui1,2,3, Nickie Andescavage1,3,4, Kushal Kapse1, Muhammad G Saleh5,6, Richard AE Edden 7,8, Catherine Limperopoulos1,2,3
1Developing Brain Institute, Children's National Hospital, Washington DC, United States of America
2Department of Radiology, George Washington University, Washington, United States of America
3Department of Pediatrics, George Washington University, Washington, United States of America
4Division of Neonatology, Children's National Hospital, Washington DC, United States of America
5Children's Hospital of Philadelphia, Philadelphia, United States of America
6Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America
7The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United States of America
8F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, United States of America
Presenting Author: Richard AE Edden

Synopsis

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References

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2. Tomiyasu M, Aida N, Shibasaki J, Umeda M, Murata K, Heberlein K, et al. In vivo estimation of gamma-aminobutyric acid levels in the neonatal brain. NMR Biomed. 2017;30(1). doi: 10.1002/nbm.3666 [doi]
3. Harris AD, Puts NA, Barker PB, Edden RA. Spectral-editing measurements of GABA in the human brain with and without macromolecule suppression. Magn Reson Med. 2015;74(6):1523-9. doi: 10.1002/mrm.25549 [doi]
4. Edden RA, Intrapiromkul J, Zhu H, Cheng Y, Barker PB. Measuring T2 in vivo with J-difference editing: application to GABA at 3 Tesla. J Magn Reson Imaging. 2012;35(1):229-34. doi: 10.1002/jmri.22865 [doi]
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7. Hui SCN, Saleh MG, Zöllner HJ, Oeltzschner G, Fan H, Li Y, et al. MRSCloud: A cloud-based MRS tool for basis set simulation. Magn Reson Med. 2022;88(5):1994-2004. doi: 10.1002/mrm.29370 [doi]
8. Near J, Simpson R, Cowen P, Jezzard P. Efficient gamma-aminobutyric acid editing at 3T without macromolecule contamination: MEGA-SPECIAL. NMR Biomed. 2011;24(10):1277-85. doi: 10.1002/nbm.1688 [doi]
9. Marjanska M, Deelchand DK, Hodges JS, McCarten JR, Hemmy LS, Grant A, et al. Altered macromolecular pattern and content in the aging human brain. NMR Biomed. 2018;31(2). doi: 10.1002/nbm.3865 [doi]
10. Braga JD, Thongngam M, Kumrungsee T. Gamma-aminobutyric acid as a potential postbiotic mediator in the gut-brain axis. NPJ Sci Food. 2024;8(1):16. doi: 10.1038/s41538-024-00253-2 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/562-05-014