Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
565-01-010 ISMRM Abstract

The Choroid Plexus in Brain Waste Clearance: Key Predictors of Volume and Impact on Aβ Deposition Under Anti-Amyloid Therapy

Primary: Neuro - Neurofluids
Secondary: Neuro - Aging
565-01-010 · Neuroinflammation: Fluids and Flow · Wednesday, 13 May, 8:20 AM–9:15 AM · Digital Posters Row F
Keywords: Aging Choroid plexus volume Amyloid PET APOE4 Anti-amyloid treatment
Accepted
Xinyi Huang1, Qian Xiao2, Li Zhao 3, Xingfeng Shao4,5, Weijia Liu1, Ye Yao1, Yiming Wang6,7, Yao Li1, Zixuan Lin8, Dengrong Jiang1
1National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), Shanghai Jiao Tong University, Shanghai 200240, China
2Department of Statistics, School of Mathematical Sciences, Shanghai JiaoTong University, Shanghai, China
3College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China
4Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
5Faculty of Medical Imaging Technology, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
6Bayer Healthcare Company Limited, Guangzhou, China
7Department of Radiology, Mayo Clinic, Rochester, United States of America
8Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China
Presenting Author: Li Zhao

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References

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7. Li J, Hu Y, Xu Y, Feng X, Meyer CH, Dai W, Zhao L. Associations between the choroid plexus and tau in Alzheimer's disease using an active learning segmentation pipeline. Fluids Barriers CNS 2024;21:56. doi:10.1186/s12987-024-00554-4 [doi]
8. Li J, Gao Y, Xu Y, Dai W, Hu Y, Feng X, Wu D, Zhao L. Morphological changes of the choroid plexus in the lateral ventricle across the lifespan: 5551 subjects from fetus to elderly. Neuroimage 2025;318:121392. doi:10.1016/j.neuroimage.2025.121392 [doi]
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10. Sperling RA, Donohue MC, Raman R et al. Trial of Solanezumab in Preclinical Alzheimer's Disease. N Engl J Med 2023;389:1096-1107. doi:10.1056/NEJMoa2305032 [doi]
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Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/565-01-010