Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
370-04-028 ISMRM Abstract

Atrophy in cortical thickness, cognitive deficits, and their transcriptomic signatures in patients with non-neuropsychiatric

Primary: Brain Function and fMRI - fMRI & Neuromodulation
Secondary: Brain Function and fMRI - fMRI Analysis
370-04-028 · Analysis in Neurodegenerative Disease · Monday, 11 May, 1:50 PM–2:45 PM · Traditional Posters | Exhibition Hall
Keywords: Transcriptional signatures Gene expression analysis Brain structure Systemic Lupus Erythematosus
Accepted
yuxuan Shang 1, Peng Li2,3,4,5, Wen Wang2,6,7,8,9
1Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Shaanxi, China
2Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, China
3Department of Medical Imaging, Nuclear Industry 215 Hospital of Shaanxi Province, Xianyang, China
4The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
5Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
6Tangdu Hospital, Fourth Military Medical University — Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province,7T MRI Precision Neurology Platform of Shaanxi Province, xi'an, China
7Tangdu Hospital, Fourth Military Medical University, Xi'an, China
8Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province,7T MRI Precision Neurology Platform of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University — Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province,7T MRI Precision Neurology Platform of Shaanxi Province, xi'an, China
97T MRI Precision Neurology Platform of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, China
Presenting Author: yuxuan Shang

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References

1. 1 Aringer, M., Costenbader, K., Daikh, D. et al. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Annals of the Rheumatic Diseases, 78(9), 1151-1159.doi: 10.1136/annrheumdis-2018-214819. [doi]
2. 2 Erica Moore. et al. Advances in the diagnosis, pathogenesis and treatment of neuropsychiatric systemic lupus erythematosus. Current opinion rheumatology. 32(2):152-158. doi: 10.1097/BOR.0000000000000682. [doi]
3. 3 Fischl, B., & Dale, A. M. et al. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Sciences.100, 636-649, doi: 10.1073/pnas.200033797. [doi]
4. 4 Seeley, W. W., Menon, V., Schatzberg, A. F. et al. Dissociable intrinsic connectivity networks for salience processing and executive control. Journal of Neuroscience, 27(9), 2349-2356. doi: 10.1523/JNEUROSCI.5587-06.2007. [doi]
5. 5 Bacchler, E. C., Batliwalla, F. M., Karypis, G., et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proceedings of the National Academy of Sciences, 100(5), 2610-2615., doi: 10.1073/pnas.0337679100. [doi]
6. 6 Bialas, A. R., & Stevens, B. et al. TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement. Nature Neuroscience, 16(12), doi: 10.1038/nn.3560 [doi]
7. 7 Huang, E. J., & Reichardt, L. F. et al. Neurotrophins: roles in neuronal development and function. Annual Review of Neuroscience, 24(1), 677-736.doi: 10.1146/annurev.neuro.24.1.677. [doi]

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http://echo.ismrm.org/p/ISMRM2026/370-04-028