Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
564-04-005 ISMRM Abstract

Reduced Brain Serotonergic Metabolites in Depression Detected by CEST MRI

Primary: Neuro - Psychiatric Disorders
Secondary: Contrast Mechanisms - CEST / APT / NOE
564-04-005 · Imaging Depression · Wednesday, 13 May, 2:35 PM–3:30 PM · Digital Posters Row E
Keywords: Depression CEST MRI Serotonergic Metabolites
Accepted
Joseph H.C. Lai 1,2, Xiang Wang1, Yang Liu3, Jianpan Huang4, Canghao Sun1, Shulan Qiu1, Weixiong Zhang1, Jing Cai1, Tian Li1
1Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hong Kong
2University Research Facility in Behavioral and Systems Neuroscience, The Hong Kong Polytechnic University, Hong Kong, Hong Kong
3Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China
4Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China
Presenting Author: Joseph H.C. Lai

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References

1. Strawbridge R, Young AH, Cleare AJ. Biomarkers for depression: Recent insights, current challenges and future prospects. Neuropsychiatr Dis Treat. 2017;13:1245-1262. doi:10.2147/NDT.S114542 [doi]
2. Lai JHC, Sun C, Liu Y, et al. CEST MRI of Regional Molecular Changes in the Brain for Depression Assessment. In: 2025 ISMRM & ISMRT Annual Meeting & Exhibition. ; 2025.
3. Qi K, Li H, Tao J, et al. Glutamate chemical exchange saturation transfer (GluCEST) MRI to evaluate the relationship between demyelination and glutamate content in depressed mice. Behavioural Brain Research. 2024;476. doi:10.1016/j.bbr.2024.115247 [doi]
4. Li H, Luo X, Qi K, et al. Glutamate Chemical Exchange Saturation Transfer (GluCEST) MRI to Evaluate the Rapid Antidepressant Effects of Ketamine in the Hippocampus of Rat Depression Model. Journal of Magnetic Resonance Imaging. 2023;59(4):1373-1381. doi:10.1002/jmri.28921 [doi]
5. Lee D, Woo CW, Heo H, et al. Mapping Changes in Glutamate with Glutamate-Weighted MRI in Forced Swim Test Model of Depression in Rats. Biomedicines. 2024;12(2). doi:10.3390/biomedicines12020384 [doi]
6. Luo X, Ren Q, Luo M, et al. Glutamate Chemical Exchange Saturation Transfer Imaging and Functional Alterations of Hippocampus in Rat Depression Model: A Pilot Study. Journal of Magnetic Resonance Imaging. 2021;54(6):1967-1976. doi:10.1002/jmri.27850 [doi]
7. Pankowska A, Chudzik A, Słowik T, et al. Saturation transfer MRI is sensitive to neurochemical changes in the rat brain due to chronic unpredictable mild stress. Sci Rep. 2021;11(1). doi:10.1038/s41598-021-97991-0 [doi]
8. Oglesby RT, Lam WW, Stanisz GJ. In vitro characterization of the serotonin biosynthesis pathway by CEST MRI. Magn Reson Med. 2020;84(5):2389-2399. doi:10.1002/mrm.28281 [doi]
9. Willner P. The chronic mild stress (CMS) model of depression: History, evaluation and usage. Neurobiol Stress. 2017;6:78-93. doi:10.1016/j.ynstr.2016.08.002 [doi]
10. Huang J, Chen Z, Park S weon, Lai JHC, Chan KWY. Molecular Imaging of Brain Tumors and Drug Delivery Using CEST MRI : Promises and Challenges. Pharmaceutics. 2022;14(451):1-26. https://www.mdpi.com/1999-4923/14/2/451.
11. Jones CK, Polders D, Hua J, et al. In vivo three-dimensional whole-brain pulsed steady-state chemical exchange saturation transfer at 7 T. Magn Reson Med. 2012;67(6):1579-1589. doi:10.1002/mrm.23141 [doi]
12. Cai K, Singh A, Poptani H, et al. CEST signal at 2ppm (CEST at 2ppm) from Z-spectral fitting correlates with creatine distribution in brain tumor. NMR Biomed. 2015;28(1):1-8. doi:10.1002/nbm.3216 [doi]
13. Terreno E, Stancanello J, Longo D, et al. Methods for an improved detection of the MRI-CEST effect. Contrast Media Mol Imaging. 2009;4(5):237-247. doi:10.1002/cmmi.290 [doi]
14. Seo JS, Mantas I, Svenningsson P, Greengard P. Ependymal cells-CSF flow regulates stress-induced depression. Mol Psychiatry. 2021;26(12):7308-7315. doi:10.1038/s41380-021-01202-1 [doi]
15. Alexander B, Warner-Schmidt J, Eriksson TM, et al. Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens. Sci Transl Med. 2010. https://www.science.org.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/564-04-005