Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
464-05-003 ISMRM Abstract

Brain segmentation in alcohol-exposed neonates: a comparison of BabySeg to Infant FreeSurfer and manual tracing

Primary: Analysis Methods - Segmentation and Detection
Secondary: Neuro - Development
464-05-003 · MR-Based Quantitative Image and Image Processing · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row E
Keywords: Software Tools Infant brain MRI Segmentation Quality Fetal alcohol exposure
Accepted
Fleur L Warton 1,2, Frances C Robertson1,2,3, R C Carter4, Andre J van der Kouwe5, Lilla Zöllei5, Neil Dodge6, Joseph Jacobson6, Sandra Jacobson6, Ernesta Meintjes1,2,3
1Biomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa
2Neuroscience Institute, University of Cape Town, South Africa
3Cape Universities Body Imaging Centre (CUBIC), Cape Town, South Africa
4Columbia University Irving Medical Center, New York, United States of America
5Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, United States of America
6Wayne State University, Detroit, United States of America
Presenting Author: Fleur L Warton

Synopsis

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References

1. Prastawa M, Gilmore J, Lin W, et al. Automatic segmentation of MR images of the developing newborn brain. Med Image Anal. 2005;9(5):457-66. doi: 10.1016/j.media.2005.05.007 [doi]
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3. Warton F, Meintjes E, Warton C, et al. Prenatal methamphetamine exposure is associated with reduced subcortical volumes in neonates. Neurotoxicol Teratol. 2018;65:51-9. doi: 10.1016/j.ntt.2017.10.005 [doi]
4. Spann M, Bansal R, Rosen T, et al. Morphological features of the neonatal brain support development of subsequent cognitive, language, and motor abilities. Hum Brain Mapp. 2014;35(9):4459-74. doi: 10.1002/hbm.22487 [doi]
5. Cheong J, Thompson D, Spittle A, et al. Brain volumes at term-equivalent age are associated with 2-year neurodevelopment in moderate and late preterm children. J Pediatr. 2016;174:91-97.e1. doi: 10.1016/j.jpeds.2016.04.002 [doi]
6. Zöllei L, Iglesias J, Ou Y. Infant FreeSurfer: an automated segmentation and surface extraction pipeline for T1-weighted neuroimaging data of infants 0-2 years. NeuroImage. 2020;218:116946. doi: 10.1016/j.neuroimage.2020.116946 [doi]
7. Hoffmann M, *Dalca A, *Zöllei L. Deep infant brain segmentation from multi-contrast MRI. Asilomar Conference on Signals, Systems, and Computers. 2025; Pacific Grove, CA, USA. Website: https://w3id.org/babyseg
8. Jacobson S, Jacobson J, Molteno C, et al. Heavy prenatal alcohol exposure is related to smaller corpus callosum in newborn MRI scans. Alc Clin Exp Res. 2017;41(5):965-75. doi: 10.1111/acer.13363 [doi]
9. van der Kouwe A, Benner T, Salat D, et al. Brain morphometry with multiecho MPRAGE. NeuroImage. 2008;40:559–69. doi: 10.1016/j.neuroimage.2007.12.025 [doi]
10. Fischl B, Salat D, van der Kouwe A, et al. Sequence-independent segmentation of magnetic resonance images. NeuroImage. 2004;23(Suppl.1):S69-84. doi: 10.1016/j.neuroimage.2004.07.016 [doi]
11. Hoyme H, May P, Kalberg W, et al. A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 institute of medicine criteria. Pediatrics. 2005; 115(1):39-47. doi: 10.1542/peds.2004-0259 [doi]

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http://echo.ismrm.org/p/ISMRM2026/464-05-003