Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
551-03-017 / 551-03-017 ISMRM Abstract

Fast, SAR-efficient Neuromelanin Imaging and Automated Segmentation of the Locus Coeruleus in AD-Related Disorders(ADRD)

Primary: Neuro - Alzheimer's Disease
Secondary: Neuro - Dementia
551-03-017 · Advanced MRI Biomarkers of Brain Aging, Vascular Health, and Alzheimer’s Disease · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 1
551-03-017 · Advanced MRI Biomarkers of Brain Aging, Vascular Health, and Alzheimer’s Disease · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 1
Keywords: Alzheimer's Disease Down Syndrome Locus Coeruleus Neuromelanin-Sensitive MRI Magnetization transfer (MT)
Accepted
Se-Hong Oh1,2, Ken Sakaie 2,3, Douglas J Martin4, Gawon Lee1, Katherine A Koenig2,3,5, Brian S Appleby6,7, Muralidhar Pallaki8,9, Karin P Mente7,10, Peijun Chen6,11, Jagan Pillai3,12, Mark Lowe2,3,4,5
1Department of Biomedical Engineering, Hankuk university of Foreign Studies, gyeonggi-do, Korea, Republic of
2Diagnostic Radiology, Cleveland Clinic, Cleveland, United States of America
3Cleveland Clinic, Cleveland, United States of America
4Imaging Institute, Cleveland Clinic, Cleveland, United States of America
5Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, United States of America
6Case Western Reserve University School of Medicine, Cleveland, United States of America
7Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, United States of America
8Geriatric Research Education and Clinical Center and Geriatric Medicine, VA Northeast Ohio Healthcare System, Cleveland, United States of America
9Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, United States of America
10Neurology, Case Western Reserve University School of Medicine, Cleveland, United States of America
11Geriatric Research Education and Clinical Center and Psychiatry Service, VA Northeast Ohio Healthcare System, Cleveland, United States of America
12Center for Brain Health, Cleveland Clinic, Cleveland, United States of America
Presenting Author: Ken Sakaie

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References

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9. Saternos H, Hamlett ED, Guzman S, Head E, Granholm AC, Ledreux A. Unique Pathology in the Locus Coeruleus of Individuals with Down Syndrome. J Alzheimers Dis. 2024;101(2):541-61. doi: 10.3233/JAD-240043. PubMed PMID: 39213062; PMCID: PMC12101226. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/551-03-017