Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
465-01-001 ISMRM Abstract

Evidence of compartmentalized redox equilibria in hyperpolarized 13C MRI of the brain

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)
Secondary: Acquisition & Reconstruction - Signal Modeling
465-01-001 · Hyperpolarization: Novel Applications · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row F
Keywords: MRI simulation 1-13C Pyruvate Lactate Computational modeling Hyperpolarized 13C
Accepted
Dylan A Dingwell 1,2, Biranavan Uthayakumar1,2, Nicole Cappelletto1,2, Albert P Chen3, Hany Soliman4, Charles H Cunningham1,2
1Department of Medical Biophysics, University of Toronto, Toronto, Canada
2Physical Sciences, Sunnybrook Research Institute, Toronto, Canada
3GE Healthcare, Taichung, Taiwan
4Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada
Presenting Author: Dylan A Dingwell

Synopsis

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References

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2. Brindle, K. M. Imaging Metabolism with Hyperpolarized (13)C-Labeled Cell Substrates. J. Am. Chem. Soc. 2015, 137 (20), 6418–6427. https://doi.org/10.1021/jacs.5b03300. [doi]
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8. Dingwell, D. A.; Cunningham, C. H. Particle-Based MR Modeling with Diffusion, Microstructure, and Enzymatic Reactions. Magn. Reson. Med. 2025, 93 (1), 369–383. https://doi.org/10.1002/mrm.30279. [doi]
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10. Loken, C.; Gruner, D.; Groer, L.; Peltier, R.; Bunn, N.; Craig, M.; Henriques, T.; Dempsey, J.; Yu, C.-H.; Chen, J.; Dursi, L. J.; Chong, J.; Northrup, S.; Pinto, J.; Knecht, N.; Zon, R. V. SciNet: Lessons Learned from Building a Power-Efficient Top-20 System and Data Centre. J. Phys. Conf. Ser. 2010, 256 (1), 012026. https://doi.org/10.1088/1742-6596/256/1/012026. [doi]
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Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/465-01-001