Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
560-03-004 ISMRM Abstract

Integrated Anatomical-Hemodynamic Analysis in Bicuspid Aortic Valve

Primary: Cardiovascular - Vascular and Vessel Wall
Secondary: Analysis Methods - Image Registration and Alignment
560-03-004 · Congenital Heart Disease, Valves, and Vessels · Wednesday, 13 May, 1:40 PM–2:35 PM · Digital Posters Row A
Keywords: Image registration 4D flow MRI Bicuspid Aortic Valve Thoracic Aortic Diseases Wall shear stress
Accepted
Charilaos Apostolidis1, Ethan Johnson2, Bradley D Allen2, Aggelos K Katsaggelos1, Michael Markl2
1Electrical and Computer Engineering, Northwestern University, Chicago, United States of America
2Radiology, Northwestern University, Chicago, United States of America
Presenting Author: Haben Berhane

Synopsis

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References

1. Tessler I, Albuisson J, Goudot G, et al. Bicuspid Aortic Valve: Genetic and Clinical Insights. Aorta (Stamford). 2021;09(04):139-146. doi:10.1055/s-0041-1730294 [doi]
2. Sillesen A, Axelsson R, Boesgaard TL, et al. Prevalence of bicuspid aortic valve and associated aortopathy in newborns in Copenhagen, Denmark. JAMA Netw Open. 2021;4(2):e2037345. doi:10.1001/jamanetworkopen.2020.37345 [doi]
3. Isselbacher EM, Preventza O, Hamilton Black J, et al. 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2022;146(24). doi:10.1161/CIR.0000000000001106 [doi]
4. Pape LA, Tsai TT, Isselbacher EM, et al. Aortic Diameter ≥5.5 cm Is Not a Good Predictor of Type A Aortic Dissection: Observations From the International Registry of Acute Aortic Dissection (IRAD). Circulation. 2007;116(10):1120-1127. doi:10.1161/CIRCULATIONAHA.107.702720 [doi]
5. Mansour AM, Peterss S, Zafar MA, et al. Prevention of Aortic Dissection Suggests a Diameter Shift to a Lower Aortic Size Threshold for Intervention. Cardiology. 2018;139(3):139-146. doi:10.1159/000481930 [doi]
6. Soulat G, Scott MB, Allen BD, et al. Association of Regional Wall Shear Stress and Progressive Ascending Aorta Dilation in Bicuspid Aortic Valve. JACC: Cardiovascular Imaging. 2022;15(1):33-42. doi:10.1016/j.jcmg.2021.06.020 [doi]
7. Minderhoud SCS, Roos-Hesselink JW, Chelu RG, et al. Wall shear stress angle is associated with aortic growth in bicuspid aortic valve patients. European Heart Journal - Cardiovascular Imaging. 2022;23(12):1680-1689. doi:10.1093/ehjci/jeab290 [doi]
8. Guala A, Dux-Santoy L, Teixido-Tura G, et al. Wall Shear Stress Predicts Aortic Dilation in Patients With Bicuspid Aortic Valve. JACC: Cardiovascular Imaging. 2022;15(1):46-56. doi:10.1016/j.jcmg.2021.09.023 [doi]
9. Bollache E, Guzzardi DG, Sattari S, et al. Aortic valve-mediated wall shear stress is heterogeneous and predicts regional aortic elastic fiber thinning in bicuspid aortic valve-associated aortopathy. The Journal of Thoracic and Cardiovascular Surgery. 2018;156(6):2112-2120.e2. doi:10.1016/j.jtcvs.2018.05.095 [doi]
10. Markl M, Frydrychowicz A, Kozerke S, et al. 4D flow MRI. J Magn Reson Imaging. 2012;36(5):1015-1036. doi:10.1002/jmri.23632 [doi]
11. Apostolidis C, Berhane H, Dushfunian D, Johnson E, Pfister C, Allen BD, Katsaggelos A, Markl M. AI-Driven Assessment of Aortic Dimensions Based on Contrast-Enhanced MRA of the Thoracic Aorta. J Cardiovasc Magn Reson. 2025;27:101478. doi:10.1016/j.jocmr.2024.101478 [doi]
12. Berhane H, Scott M, Elbaz M, et al. Fully automated 3D aortic segmentation of 4D flow MRI for hemodynamic analysis using deep learning. Magn Reson Med. 2020;84(4):2204-2218. doi:10.1002/mrm.28257 [doi]
13. Çiçek Ö, Abdulkadir A, Lienkamp SS, Brox T, Ronneberger O. 3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation. Published online June 21, 2016. Accessed January 22, 2024. http://arxiv.org/abs/1606.06650
14. Huang G, Liu Z, Van Der Maaten L, Weinberger KQ. Densely Connected Convolutional Networks. In: 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR). IEEE; 2017:2261-2269. doi:10.1109/CVPR.2017.243 [doi]
15. Johnson EMI, Berhane H, Weiss E, et al. A Fully Automated Analysis Pipeline for 4D Flow MRI in the Aorta. Bioengineering. 2025;12(8):807. doi:10.3390/bioengineering12080807 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/560-03-004