Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-05-006 ISMRM Abstract

First In-Vivo Hyperpolarized Xenon-129 Imaging Utilizing an Asymmetrical Birdcage Coil

Primary: Physics & Engineering - Non-Array RF Coils, Antennas & Waveguides
Secondary: Contrast Mechanisms - Hyperpolarized MR (Gas)
369-05-006 · Hyperpolarized Gases · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row J
Keywords: Pulmonary Imaging In Vivo Hyperpolarized Xenon-129 MRI Gas Exchange Asymmetrical Birdcage Coil
Accepted
Wolfgang Loew 1,2, Matthew M Willmering3,4, Laura Walkup3,4,5, Jason Woods2,3,4, Charles Dumoulin1,2,4
1Department of Radiology - Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
2Department of Radiology, University of Cincinnati, Cincinnati, United States of America
3Division of Pulmonary Medicine - Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, United States of America
4Department of Pediatrics, University of Cincinnati, Cincinnati, United States of America
5Department of Biomedical Engineering, University of Cincinnati, Cincinnati, United States of America
Presenting Author: Wolfgang Loew

Synopsis

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References

1. 1. Stewart NJ, Horn FC, Norquay G, Collier GJ, Yates DP, Lawson R, Marshall H, Wild JM. Reproducibility of quantitative indices of lung function and microstructure from 129 Xe chemical shift saturation recovery (CSSR) MR spectroscopy. Magn Reson Med. 2017 Jun;77(6):2107-2113. doi: 10.1002/mrm.26310. Epub 2016 Jul 1. PMID: 27366901; PMCID: PMC5484314. [doi] [pmid]
2. 2. Kaushik SS, Robertson SH, Freeman MS, He M, Kelly KT, Roos JE, Rackley CR, Foster WM, McAdams HP, Driehuys B. Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition. Magn Reson Med. 2016 Apr;75(4):1434-43. doi: 10.1002/mrm.25675. Epub 2015 May 18. PMID: 25980630; PMCID: PMC4651856. [doi] [pmid]
3. 3. Ruppert K, Altes TA, Mata JF, Ruset IC, Hersman FW, Mugler JP 3rd. Detecting pulmonary capillary blood pulsations using hyperpolarized xenon-129 chemical shift saturation recovery (CSSR) MR spectroscopy. Magn Reson Med. 2016 Apr;75(4):1771-80. doi: 10.1002/mrm.25794. Epub 2015 May 28. PMID: 26017009; PMCID: PMC6154503. [doi] [pmid]
4. 4. Niedbalski PJ, Hall CS, Castro M, Eddy RL, Rayment JH, Svenningsen S, Parraga G, Zanette B, Santyr GE, Thomen RP, Stewart NJ, Collier GJ, Chan HF, Wild JM, Fain SB, Miller GW, Mata JF, Mugler JP 3rd, Driehuys B, Willmering MM, Cleveland ZI, Woods JC. Protocols for multi-site trials using hyperpolarized 129 Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129 Xe MRI clinical trials consortium. Magn Reson Med. 2021 Dec;86(6):2966-2986. doi: 10.1002/mrm.28985. Epub 2021 Sep 3. PMID: 34478584. [doi] [pmid]
5. 5. Bdaiwi AS, Willmering MM, Plummer JW, Hussain R, Roach DJ, Parra-Robles J, Niedbalski PJ, Woods JC, Walkup LL, Cleveland ZI. 129Xe Image Processing Pipeline: An open-source, graphical user interface application for the analysis of hyperpolarized 129Xe MRI. Magn Reson Med. 2025 Mar;93(3):1220-1237. doi: 10.1002/mrm.30347. Epub 2024 Oct 31. PMID: 39480807; PMCID: PMC11680735. [doi] [pmid]
6. 6. Niedbalski PJ, Willmering MM, Robertson SH, Freeman MS, Loew W, Giaquinto RO, Ireland C, Pratt RG, Dumoulin CL, Woods JC, Cleveland ZI. Mapping and correcting hyperpolarized magnetization decay with radial keyhole imaging. Magn Reson Med. 2019 Jul;82(1):367-376. doi: 10.1002/mrm.27721. Epub 2019 Mar 7. PMID: 30847967; PMCID: PMC6491256. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/369-05-006