Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
561-02-013 ISMRM Abstract

Relaxometry-Based Classification of Human Knee Cartilage Degeneration

Primary: Musculoskeletal - Cartilage
Secondary: Contrast Mechanisms - Relaxometry
561-02-013 · Classification and Analysis in the Body · Wednesday, 13 May, 9:15 AM–10:10 AM · Digital Posters Row B
Keywords: Cartilage Relaxometry Quantitative MRI
Accepted
Ville Kantola 1, Marvin Werner1, Ville-Pauli Karjalainen1, Mikko J Nissi2,3, Victor Casula1, Miika T Nieminen1,4,5
1Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland
2University of Eastern Finland, Kuopio, Finland
3Department of Technical Physics, University of Eastern Finland, Kuopio, Finland
4Department of Diagnostics, Oulu University Hospital, Oulu, Finland
5Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
Presenting Author: Ville Kantola

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Aaron RK, Racine J. Pathogenesis and Epidemiology of Osteoarthritis. R I Med J. 2013;96(3):19-22.
2. Steinmetz JD, Culbreth GT, Haile LM, et al. Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023;5(9):e508-e522. doi:10.1016/S2665-9913(23)00163-7 [doi]
3. Pritzker KPH, Gay S, Jimenez SA, et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage. 2006;14(1):13-29. doi:10.1016/j.joca.2005.07.014 [doi]
4. Casula V, Kajabi AW. Quantitative MRI methods for the assessment of structure, composition, and function of musculoskeletal tissues in basic research and preclinical applications. Magn Reson Mater Phys Biol Med. June 2024. doi:10.1007/s10334-024-01174-7 [doi]
5. Berberat JE, Nissi MJ, Jurvelin JS, Nieminen MT. Assessment of interstitial water content of articular cartilage with T1 relaxation. Magn Reson Imaging. 2009;27(5):727-732. doi:10.1016/j.mri.2008.09.005 [doi]
6. Lüssea S, Claassen H, Gehrke T, et al. Evaluation of water content by spatially resolved transverse relaxation times of human articular cartilage. Magn Reson Imaging. 2000;18(4):423-430. doi:10.1016/S0730-725X(99)00144-7 [doi]
7. Liess C, Lüsse S, Karger N, Heller M, Glüer CC. Detection of changes in cartilage water content using MRI T2-mapping. Osteoarthritis Cartilage. 2002;10(12):907-913. doi:10.1053/joca.2002.0847 [doi]
8. Nieminen MT, Rieppo J, Töyräs J, et al. T 2 relaxation reveals spatial collagen architecture in articular cartilage: A comparative quantitative MRI and polarized light microscopic study: T 2 Imaging of Articular Cartilage. Magn Reson Med. 2001;46(3):487-493. doi:10.1002/mrm.1218 [doi]
9. Nieminen MT, Töyräs J, Laasanen MS, Silvennoinen J, Helminen HJ, Jurvelin JS. Prediction of biomechanical properties of articular cartilage with quantitative magnetic resonance imaging. J Biomech. 2004;37(3):321-328. doi:10.1016/S0021-9290(03)00291-4 [doi]
10. Nissi MJ, Töyräs J, Laasanen MS, et al. Proteoglycan and collagen sensitive MRI evaluation of normal and degenerated articular cartilage. J Orthop Res. 2004;22(3):557-564. doi:10.1016/j.orthres.2003.09.008 [doi]
11. Nissi MJ MJ, Salo EN, Tiitu V, et al. Multi-Parametric MRI Characterization of Enzymatically Degraded Articular Cartilage. J Orthop Res Off Publ Orthop Res Soc. 2016;34(7):1111-1120. doi:10.1002/jor.23127 [doi]
12. Mlynárik V, Szomolányi P, Toffanin R, Vittur F, Trattnig S. Transverse relaxation mechanisms in articular cartilage. J Magn Reson. 2004;169(2):300-307. doi:10.1016/j.jmr.2004.05.003 [doi]
13. De Visser SK, Bowden JC, Wentrup-Byrne E, et al. Anisotropy of collagen fibre alignment in bovine cartilage: comparison of polarised light microscopy and spatially resolved diffusion-tensor measurements. Osteoarthritis Cartilage. 2008;16(6):689-697. doi:10.1016/j.joca.2007.09.015 [doi]
14. Hänninen NE, Nykänen O, Prakash M, Hanni M, Nieminen MT, Nissi MJ. Orientation anisotropy of quantitative MRI parameters in degenerated human articular cartilage. J Orthop Res. 2021;39(4):861-870. doi:10.1002/jor.24778 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/561-02-013