Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-03-007 ISMRM Abstract

MRS-visible macromolecules are elevated in Parkinson's disease and are associated with perivascular space counts

Primary: Neuro - Neurofluids
Secondary: Neuro - Parkinson's Disease
663-03-007 · Glymphatic System Imaging: From Neurofluid Transport to Neurodegeneration · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row D
Keywords: Neurodegeneration Neurofluids MR spectroscopy Glymphatic clearance
Accepted
Ruth O'Gorman Tuura 1, Lena Meinhold1, Antonio G Gennari1, Angeline Messerli1, Simon Schreiner2, Christian Baumann2, Heide Baumann-Vogel3
1Center for MR Research, University Children's Hospital Zurich, Zurich, Switzerland
2University Hospital Zurich, Zurich, Switzerland, Switzerland
3Psychiatric University Hospital Zurich, Zurich, Switzerland
Presenting Author: Ruth O'Gorman Tuura

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References

1. Cudalbu C, et al. Contribution of macromolecules to brain 1H MR spectra: Experts' consensus recommendations. https://doi.org/10.1002/nbm.4393 [doi]
2. Genovese G, et al. Age-related differences in macromolecular resonances observed in ultra-short-TE STEAM MR spectra at 7 T. doi: 10.1002/mrm.30061 [doi]
3. Marjanska M, et al. Altered macromolecular pattern and content in the aging human brain. doi: 10.1002/nbm.3865 [doi]
4. Akiyama Y, et al. Accumulation of Macromolecules in Idiopathic Normal Pressure Hydrocephalus. doi: 10.2176/nmc.oa.2020-0274 [doi]
5. Kreis R. The trouble with quality filtering based on relative Cramér-Rao lower bounds. doi: 10.1002/mrm.25568 [doi]
6. Meinhold L, et al. T2 MRI visible perivascular spaces in Parkinson’s disease: clinical significance and association with polysomnography measured sleep. doi: 10.1093/sleep/zsae233 [doi]
7. Wardlaw JM, et al. STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1). Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. doi: https://doi.org/ 10.1016/S1474-4422(13)70124-8 [doi]
8. Schaser, A.J., et al. Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders. https://doi.org/10.1038/s41598-019-47227-z [doi]
9. Braak H, et al. Staging of brain pathology related to sporadic Parkinson's disease. DOI: 10.1016/s0197-4580(02)00065-9 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/663-03-007