Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
560-03-005 ISMRM Abstract

Impact of water exchange on estimates of myocardial blood flow & ECV using DCE-MRI in patients treated for aortic stenosis

Primary: Contrast Mechanisms - Perfusion
Secondary: Cardiovascular - Myocardium
560-03-005 · Congenital Heart Disease, Valves, and Vessels · Wednesday, 13 May, 1:40 PM–2:35 PM · Digital Posters Row A
Keywords: Myocardial Blood Flow Dynamic contrast enhanced MRI Water exchange Aortic stenosis Extracellular volume fraction
Accepted
Alex Makins1, John D Biglands1, Noor Sharrack2, Peter Kellman3, Sven Plein2, David L Buckley 2
1Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
2Biomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom
3NHLBI, NIH, Bethesda, Maryland, United States of America
Presenting Author: David L Buckley

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References

1. Judd RM, Reeder SB, May-Newman K. Effects of water exchange on the measurement of myocardial perfusion using paramagnetic contrast agents. Magn Reson Med 1999;41(2):334-342 doi:10.1002/(sici)1522-2594(199902)41:2<334::aid-mrm18>3.0.co;2-y. [doi]
2. Li X, Springer CS, Jr., Jerosch-Herold M. First-pass dynamic contrast-enhanced MRI with extravasating contrast reagent: evidence for human myocardial capillary recruitment in adenosine-induced hyperemia. NMR Biomed 2009;22(2):148-157 doi:10.1002/nbm.1293. [doi]
3. Sharrack N, Biglands JD, Broadbent DA, et al. The impact of water exchange on estimates of myocardial extracellular volume calculated using contrast enhanced T1 measurements: A preliminary analysis in patients with severe aortic stenosis. Magn Reson Med 2024;91(4):1637-1644 doi:10.1002/mrm.29956. [doi]
4. Kunze KP, Rischpler C, Hayes C, et al. Measurement of extracellular volume and transit time heterogeneity using contrast-enhanced myocardial perfusion MRI in patients after acute myocardial infarction. Magn Reson Med 2017;77(6):2320-2330 doi:10.1002/mrm.26320. [doi]
5. Kellman P, Hansen MS, Nielles-Vallespin S, et al. Myocardial perfusion cardiovascular magnetic resonance: optimized dual sequence and reconstruction for quantification. J Cardiovasc Magn Reson 2017;19(1):43 doi:10.1186/s12968-017-0355-5. [doi]
6. Chow K, Hayes G, Flewitt JA, et al. Improved accuracy and precision with three-parameter simultaneous myocardial T1 and T2 mapping using multiparametric SASHA. Magn Reson Med 2022;87(6):2775-2791 doi:10.1002/mrm.29170. [doi]
7. Buckley DL. Shutter-speed dynamic contrast-enhanced MRI: Is it fit for purpose? Magn Reson Med 2019;81(2):976-988 doi:10.1002/mrm.27456. [doi]
8. Coelho-Filho OR, Mongeon FP, Mitchell R, et al. Role of transcytolemmal water-exchange in magnetic resonance measurements of diffuse myocardial fibrosis in hypertensive heart disease. Circ Cardiovasc Imaging 2013;6(1):134-141 doi:10.1161/CIRCIMAGING.112.979815. [doi]
9. Brown LAE, Onciul SC, Broadbent DA, et al. Fully automated, inline quantification of myocardial blood flow with cardiovascular magnetic resonance: repeatability of measurements in healthy subjects. J Cardiovasc Magn Reson 2018;20(1):48 doi:10.1186/s12968-018-0462-y. [doi]

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http://echo.ismrm.org/p/ISMRM2026/560-03-005