Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
307-04-007 ISMRM Abstract

Stabilizing Histamine Release in Reperfused Myocardial Infarction Optimizes Inflammation and Mitigates Adverse Remodeling

Primary: Cardiovascular - Inflammation, Infiltration
Secondary: Cardiovascular - Heart Failure
307-04-007 · Heart Failure · Monday, 11 May, 4:10 PM–6:00 PM · Meeting Room 1.40
Keywords: Inflammation Myocardial remodeling Myocardial infarction PET-MRI
Accepted
Joao Pedro Torres Neiva Rodrigues 1, Leon Riehakainen1, Alan C Kwan2,3, Debiao Li1,4, Ivan Cokic1
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, United States of America
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States of America
3Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, United States of America
4Department of Bioengineering, University of California Los Angeles, Los Angeles, United States of America
Presenting Author: Joao Pedro Torres Neiva Rodrigues

Synopsis

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References

1. Nahrendorf, M., Pittet, M. J. & Swirski, F. K. Monocytes: Protagonists of Infarct Inflammation and Repair After Myocardial Infarction. Circulation 121, 2437–2445 (2010). doi: 10.1161/CIRCULATIONAHA.109.916346. [doi]
2. Nahrendorf, M. et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J. Exp. Med. 204, 3037–3047 (2007). doi: 10.1084/jem.20070885. [doi]
3. Ye, Y.-X. et al. Monitoring of Monocyte Recruitment in Reperfused Myocardial Infarction With Intramyocardial Hemorrhage and Microvascular Obstruction by Combined Fluorine 19 and Proton Cardiac Magnetic Resonance Imaging. Circulation 128, 1878–1888 (2013). doi: 10.1161/CIRCULATIONAHA.113.000731. [doi]
4. Laine, P. et al. Association Between Myocardial Infarction and the Mast Cells in the Adventitia of the Infarct-Related Coronary Artery. Circulation 99, 361–369 (1999). doi: 10.1161/01.cir.99.3.361. [doi]
5. Forman, M. B. et al. Increased Adventitial Mast Cells in a Patient with Coronary Spasm. N. Engl. J. Med. 313, 1138–1141 (1985). doi: 10.1056/NEJM198510313131807. [doi]
6. Dilsizian, V. et al. ASNC imaging guidelines/SNMMI procedure standard for positron emission tomography (PET) nuclear cardiology procedures. J. Nucl. Cardiol. 23, 1187–1226 (2016). doi: 10.1007/s12350-016-0522-3. [doi]
7. Osborne, M. T. et al. Patient preparation for cardiac fluorine-18 fluorodeoxyglucose positron emission tomography imaging of inflammation. J. Nucl. Cardiol. Off. Publ. Am. Soc. Nucl. Cardiol. 24, 86–99 (2017). doi: 10.1007/s12350-016-0502-7. [doi]
8. Wilk, B. et al. Tracking the progress of inflammation with PET/MRI in a canine model of myocardial infarction. J. Nucl. Cardiol. Off. Publ. Am. Soc. Nucl. Cardiol. 29, 1315–1325 (2022). doi: 10.1007/s12350-020-02487-5. [doi]

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http://echo.ismrm.org/p/ISMRM2026/307-04-007