665-03-014 ISMRM Abstract

Neurotransmitter Alterations and Glymphatic System Dysfunction in Chronic Insomnia Co-morbid with Major Depressive Disorder

Primary: Brain Function and fMRI - fMRI Analysis

Secondary: Brain Function and fMRI - fMRI & Neuromodulation

665-03-014 · fMRI: Applications in Neurology and Psychiatry III · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row F

Keywords: Glymphatic system Depression Neurotransmitter mapping Primary insomnia

Accepted

Yongqiong Tao, Lu Han ¹, Peng Wu^1,2

¹Philips Healthcare, Guangzhou, China

²Clinical & Technical Support, Philips Healthcare, Guangzhou, China

Presenting Author: Lu Han

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References

1. Plante, D.T., et al., Establishing the objective sleep phenotype in hypersomnolence disorder with and without comorbid major depression. Sleep, 2019. 42(6). http://dx.doi.org/10.1093/sleep/zsz060 [doi]

2. Chong, P.L.H., et al., Sleep, cerebrospinal fluid, and the glymphatic system: A systematic review. Sleep Medicine Reviews, 2022. 61. http://dx.doi.org/10.1016/j.smrv.2021.101572 [doi]

3. Jin, Y., et al., Glymphatic system dysfunction in middle-aged and elderly chronic insomnia patients with cognitive impairment evidenced by diffusion tensor imaging along the perivascular space (DTI-ALPS). Sleep Medicine, 2024. 115. http://dx.doi.org/10.1016/j.sleep.2024.01.028 [doi]

4. Miller, C.B., et al., An Objective Short Sleep Insomnia Disorder Subtype Is Associated With Reduced Brain Metabolite Concentrations In Vivo: A Preliminary Magnetic Resonance Spectroscopy Assessment. Sleep, 2017. 40(11). http://dx.doi.org/10.1093/sleep/zsx148 [doi]

5. Yao, Y., et al., An overview of mechanisms underlying the comorbidity of sleep and depression disorders in the elderly. Stress and Brain, 2024. 4(1). http://dx.doi.org/10.26599/sab.2023.9060007 [doi]

6. Si, X., et al., Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson’s disease. npj Parkinson's Disease, 2022. 8(1). http://dx.doi.org/10.1038/s41531-022-00316-9 [doi]

7. Nothdurfter, D., P. Jawinski, and S. Markett, White Matter Tract Integrity Is Reduced in Depression and in Individuals With Genetic Liability to Depression. Biological Psychiatry, 2024. 95(12). http://dx.doi.org/10.1016/j.biopsych.2023.11.028 [doi]

8. Ning, J., et al., Association of sleep behaviors with white matter hyperintensities and microstructural injury: a cross-sectional and longitudinal analysis of 26 354 participants. Sleep, 2023. 46(5). http://dx.doi.org/10.1093/sleep/zsad020 [doi]

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http://echo.ismrm.org/p/ISMRM2026/665-03-014