Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
401-04-005 ISMRM Abstract

Cancer treatment-induced cardiotoxicity detection and cardioprotection Monitoring from SGLT2i using multimodal MR biomarkers

Primary: Cardiovascular - Heart Failure
Secondary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)
401-04-005 · Metabolism · Tuesday, 12 May, 4:00 PM–5:50 PM · Hall 1A
Keywords: Cardiomyopathy Metabolism Treatment Response 1-13C Pyruvate Cardiotoxicity
Accepted
Donghyun Hong 1, Yoo Jin Hong2, Xiao Ji3,4, Manushka Vaidya1, Umesh Masharani5, George A Brooks6, Avantika Sinha1,7, Renuka Sriram1, Dan Vigneron1,8, Roselle Abraham9, Peder Larson1
1Department of Radiology and Biomedical Imaging, University Of California, San Francisco (UCSF), United States of America
2Radiology, Yonsei University College of Medicine, Seoul, Korea, Republic of
3Department of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China
4Core Research Facility, West China Hospital of Sichuan University, Chengdu, China
5Department of Medicine, University Of California, San Francisco (UCSF), United States of America
6Department of Integrative Biology, University of California, Berkeley, United States of America
7UCSF-UC Berkeley Graduate Program in Bioengineering, United States of America
8Department of Neurological Surgery, University Of California, San Francisco (UCSF), United States of America
9Department of Cardiology, University Of California, San Francisco (UCSF), United States of America
Presenting Author: Donghyun Hong

Synopsis

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References

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2. Cardinale D, Colombo A, Bacchiani G, Tedeschi I, Meroni CA, Veglia F, Civelli M, Lamantia G, Colombo N, Curigliano G. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation 2015;131(22):1981-1988.
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7. Kim Y, Chen HY, Autry AW, Villanueva‐Meyer J, Chang SM, Li Y, Larson PE, Brender JR, Krishna MC, Xu D. Denoising of hyperpolarized 13C MR images of the human brain using patch‐based higher‐order singular value decomposition. Magnetic resonance in medicine 2021;86(5):2497-2511.
8. Sahin S, Garnæs MF, Bennett A, Dwork N, Tang S, Liu X, Vaidya M, Wang ZJ, Larson PE. A pharmacokinetic model for hyperpolarized 13C‐pyruvate MRI when using metabolite‐specific bSSFP sequences. Magnetic Resonance in Medicine 2024;92(4):1698-1713.
9. Chistiakov DA, Shkurat TP, Melnichenko AA, Grechko AV, Orekhov AN. The role of mitochondrial dysfunction in cardiovascular disease: a brief review. Annals of medicine 2018;50(2):121-127.
10. Timm KN, Perera C, Ball V, Henry JA, Miller JJ, Kerr M, West JA, Sharma E, Broxholme J, Logan A. Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI. Communications biology 2020;3(1):692.
11. Park JM, Reed GD, Liticker J, Putnam WC, Chandra A, Yaros K, Afzal A, MacNamara J, Raza J, Hall RG. Effect of doxorubicin on myocardial bicarbonate production from pyruvate dehydrogenase in women with breast cancer. Circulation research 2020;127(12):1568-1570.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/401-04-005