Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
667-02-013 ISMRM Abstract

Quantitative mapping of brain tumour microenvironment heterogeneity with VERDICT-MRI

Primary: Neuro - Tumors
Secondary: Diffusion - Microstructure
667-02-013 · Diffusion Microstructure and Beyond · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row H
Keywords: Microstructure Diffusion-weighted MRI Tumor microenvironment Brain Tumor Imaging VERDICT MRI
Accepted
Matteo Figini 1,2, Samuel Rot1,3, James K Ruffle4,5, Anestis Passalis3, Bhavana S Solanky1,3, Daniel C Alexander1,2, Claudia A Gandini Wheeler-Kingshott, Marco Palombo6,7, Eleftheria Panagiotaki1,2, Harpreet Hyare8
1Hawkes Institute, University College London, London, United Kingdom
2Department of Computer Science, University College London, London, United Kingdom
3NMR Research unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom
4Queen Square Institute of Neurology, University College London, London, United Kingdom
5Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
6School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom
7Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom
8Department of Translational Neuroscience and Stroke, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom
Presenting Author: Matteo Figini

Synopsis

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References

1. Villanueva-Meyer JE, Mabray MC, Cha S. Current Clinical Brain Tumor Imaging. Neurosurgery 2017;81(3):397-415. doi: 10.1093/neuros/nyx103. [doi]
2. O’Connor JPB, Rose CJ, Waterton JC, Carano RAD, Parker GJM, Jackson A. Imaging intratumor heterogeneity: role in therapy response, resistance, and clinical outcome. Clinical Cancer Research 2015, 212:249–257. doi: 10.1158/1078-0432.CCR-14-0990. [doi]
3. Figini M, Castellano A, Bailo M, Callea M, Cadioli M, Bouyagoub S, Palombo M, Pieri V, Mortini P, Falini A, Alexander DC, Cercignani M, Panagiotaki E. Comprehensive Brain Tumour Characterisation with VERDICT-MRI: Evaluation of Cellular and Vascular Measures Validated by Histology. Cancers 2023 Apr 27;15(9):2490. doi: 10.3390/cancers15092490. PMID: 37173965; PMCID: PMC10177485. doi: 10.3390/cancers15092490. [doi] [pmid]
4. Veraart, J.; Novikov, D.S.; Christiaens, D.; Ades-Aron, B.; Sijbers, J.; Fieremans, E. Denoising of diffusion MRI using random matrix theory. Neuroimage 2016, 142, 394-406. doi: 10.1016/j.neuroimage.2016.08.016. [doi]
5. Kellner, E.; Dhital, B.; Kiselev, V.G.; Reisert, M. Gibbs-ringing artifact removal based on local subvoxel-shifts. Magn Reson Med 2016, 76, 1574-1581. doi: 10.1002/mrm.26054. [doi]
6. Andersson JLR, Skare S, Ashburner J. How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging. NeuroImage 2003, 20(2):870-888. doi: 10.1016/S1053-8119(03)00336-7. [doi]
7. Nilsson, M.; Szczepankiewicz, F.; Lampinen, B.; Ahlgren, A.; de Almeida Martins, J.P.; Lasic, S.; Westin, C.-F.; Topgaard, D. An open-source framework for analysis of multidimensional diffusion MRI data implemented in MATLAB. In Proceedings of Joint Annual Meeting ISMRM-ESMRMB, Paris, France (2018); p. 5355.
8. Zhang H, Schneider T, Wheeler-Kingshott CA, Alexander DC. NODDI: practical in vivo neurite orientation disper-sion and density imaging of the human brain. Neuroimage 2012, 61, 1000-1016. doi: 10.1016/j.neuroimage.2012.03.072. [doi]
9. Ruffle JK, Mohinta S, Gray R, Hyare H, Nachev P. Brain tumour segmentation with incomplete imaging data. Brain Commun. 2023;5(2):fcad118.
10. Venkatesh HS, Johung TB, Caretti V, Noll A, Tang Y, Nagaraja S, Gibson EM, Mount CW, Polepalli J, Mitra SS, Woo PJ, Malenka RC, Vogel H, Bredel M, Mallick P, Monje M. Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion. Cell 2015; 161(4):803-16. doi: 10.1016/j.cell.2015.04.012. [doi]
11. Marino S, Menna G, Di Bonaventura R, Lisi L, Mattogno P, Figà F, Bilgin L, D’Alessandris QG, Olivi A, Della Pepa GM. The Extracellular Matrix in Glioblastomas: A Glance at Its Structural Modifications in Shaping the Tumoral Microenvironment—A Systematic Review. Cancers 2023, 15, 1879. doi: 10.3390/cancers15061879. [doi]
12. Kallenberg K, Goldmann T, Menke J, Strik H, Bock HC, Stockhammer F, Buhk JH, Frahm J, Dechent P, Knauth M. Glioma infiltration of the corpus callosum: early signs detected by DTI. J Neurooncol. 2013 Apr;112(2):217-22. doi: 10.1007/s11060-013-1049-y. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/667-02-013